NTADR R ỌR RR FREE N’efu

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Nkịtị metabolism
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Mmetọ ikuku
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Mgbasa ozi Ultraviolet
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Arụrụ dị arọ nke igwe
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Mmetọ Pesticide
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Mmetọ Pesticide

 

 

RADICALS & Ọrịa

 

Dị ka ọ na-adịkarị, ihe ndị na-eme ka ihe dị mkpa dị mkpa maka ahụ, mana oke ihe na-akpata free nwere ike ime ka adịghị arụ ọrụ physiological, wee duga nrụgide oxidative na-agbanwe n'ọrịa dị iche iche (akwụkwọ ọgụgụ na-egosi na ndị na-akpata ọrịa bụ isi iyi nke ọrịa dị iche iche).

 

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OGOCHI

 

Ahụ anyị enweghị ike ịrụ ọrụ na-enweghị oxygen, na mgbe ọnụ ọgụgụ buru ibu nke ihe ndị na-enweghị onwe ha na-abawanye, ahụ dị n'okpuru nrụgide oxidative ga-eme ka usoro ndozi ahụ ghara ịdapụ na-ewepụ radical free. N’ọnọdụ pụrụ iche, ahụ chọrọ mejupụta antioxidants in vitro iji wepu oke ihe ọkụkụ na-enweghị isi.

 

Ọganihu nke ndị ANTIOXIDANTS

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L-ERGOTHIONEINE – Tdị ỌH NEWR NEW NKE ANY AN NA-EME

 

EGT bụ ihe eke chiral amino-acid antioxidant biosynthesized na ụfọdụ bacteria na fungi. Ọ bụ ihe dị mkpa bioactive nke e jiri mee ihe dị ka onye na-atụgharị egwu, ihe ntanetị na-eme ka ultraviolet ray, onye na-achịkwa mmeghachi omume nke oxydation na cellular bioenergetics, na usoro physiology, wdg
L-Ergothioneine (EGT, ERGO, CAS: 497-30-3), makwaara dị ka (S) -α-Carboxy-2,3-dihydro-N, N, N-trimethyl-2-thioxo-1H-imidazole- Ntan 4-ethanaminium dị n’ime ya, bụ nke Tanret C wepụrụ ya na mbu na 1909, emesia achọpụtakwa n’ime ọbara anụmanụ. EGT dị ọcha bụ kristal na-acha ọcha, na-agbanye mmiri, (etisasịwo 0.9mol / L na okpomọkụ ụlọ). Xchekwa onwe onwe apughi ibia nihe omumu pH ma obu na alkaline siri ike. EGT nwere ike ịdị n'ụdị abụọ isomer - ụdị thiol na ụdị thione, dị ka egosiri n'okpuru:

 

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Mgbanwe

Na uru nke ọtụtụ ọrụ, EGT pụtara ìhè n'etiti ọtụtụ antioxidants ndị ọzọ.

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uru

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Site na uru nke ọtụtụ ọrụ, EGT pụtara ìhè n'etiti ọtụtụ ndị ọzọ antioxidants.A bara uru (ma e jiri ya tụnyere glutathione, cysteine ​​wdg):
——EGT dị mfe njupụta na mkpụrụ ndụ ma ịta ahụhụ kwụsie ike karịa antioxidants ndị ọzọ.
——EGT na-arụ ọrụ nke ọma n'ibelata ọnwụ mkpụrụ ndụ nke pyrogallol kpatara.
——EGT tumadi scavenges ROS iji gbochie ọxịdashọn, ebe glutathione na ndị ọzọ na - atụgharị ndị na - enweghị ihe ọ bụla, ya bụ, ndị ọzọ antioxidants scavenge ọxịdashọn ngwaahịa.(1) Oleoylethanolamide (oea) - anwansi anwansi nke ndu gi

AKPARKỌ ANTIOXIDATION

Results: EGT bụ onye na-arụ ọrụ kachasị arụ ọrụ nke free radicals ma e jiri ya tụnyere antioxidants kpochapụwo dịka GSH, uric acid na trolox. Karịsịa, ikike antioxidant kachasị elu nke EGT vs. peroxyl radicals gosipụtara 25% dị elu karịa uru enwetara na ntụpọ antioxidant antioxidant. Ike ntụgharị nke EGT maka hydroxyl radicals bụ 60% dị elu, ma e jiri ya tụnyere uric acid, nke na-anọchite anya ntụpọ antioxidant vs. hydroxyl radicals. N'ikpeazụ, EGT gosipụtara ọrụ antioxidant kachasị elu na-aga n'ihu peroxynitrite, yana ikike ngbachapu 10% karịa nke uric acid.

 

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OGWU NWA OMA

 

EGT nwekwara mmetụta na nhazi nke ike intracellular,

na - eme ka ihe ndị nwere ike ịdọrọ mmadụ,

mee ka nkpuru nwoke ghara idiwanye,

ikpuchi umeji site na mmerụ ahụ,

igbochi mbufụt,

nyocha,

ntụpọ na mmepe.

 

 

Mkpa nke mmepe

A NA-AHU EGT N'IME N'INLU N'ALITE NA IMLỌ

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Nkuzi

5-10mg kwa otu maka okenye na 2-3 nkeji na-aga n'ihu oriri dị oké mkpa na gị kwa ụbọchị nri.

Ebe e si nweta ya: Li Yiqun, Zhou Nianbo. Ọrụ bayoloji na Ngwa nke EGT [J]. Nchịkwa nri , 2010,9 (3) : 26-28.

Edepụtara ihe ndị dị ka ndị a:

Mụaka (afọ 3-11) 0 XNUMX mg / ụbọchị
Ntorobịa (afọ 11-21) ≤30 mg / ụbọchị
Ndị okenye (afọ 21-80) ≤30 mg / ụbọchị

Rịba ama : 1. Ọgwụ maka ụmụaka na ndị okenye (3 -80 afọ)

           2.Iji maka ụmụ nwanyị dị ime ma ọ bụ ụmụ nwanyị na-enye ara ndụmọdụ.

Isi data: Tetrahedron mgbe ị na-etinye maka US NDI

Data na-atụ aro: 10.5mg / g maka OXIS's ADI (Intakeable Daily Intake).

 

③ EBERE

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Mwepu na ntinye

(1) MB EXP.

Ka ọ dị ugbu a, ụzọ atọ maka mmepụta EGT: njikọ kemịkalụ, eke bio-mmịpụta (tumadi site na mushrooms, anụ ahụ anụ na mmịpụta ọbara), na usoro biosynthesis.

Tụnyere nke EGT mmịpụta ụzọ

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(2) NA-EME

EGT nwere ngwa sara mbara na ihe ịchọ mma, nri oriri, ọgwụ, ọgwụgwọ, biomedicine, wdg.

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(3) IHE ND OTHER ỌZỌ NA-EME

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References

  1. Oleoylethanolamide (oea) - ihe anwansi anwansi nke ndu gi
  2. Anandamide vs cbd: kedu nke ka mma maka ahụike gị? Ihe niile ị chọrọ ịma banyere ha!
  3. Ihe niile ịchọrọ ịma gbasara nicotinamide riboside chloride
  4. Mmeju nke Magnesium l-threonate: uru, onunu ogwu, na ihe ndi ozo
  5. Palmitoylethanolamide (agwa): uru, onunu ogwu, ojiji, mgbakwunye
  6. Top 6 uru uru nke resveratrol Mmeju
  7. Top 5 uru nke ị ofụ phosphatidylserine (ps)
  8. Ihe nlekọta 5 kacha elu na-ewere pyrroloquinoline quinone (pqq)
  9. Ihe kacha mma nootropic nke alpha gpc
  10. Ngwunye kachasị mma nke ịka nká nke nicotinamide mononucleotide (nmn)

 

Nkeji edemede site : Dr. Zeng

Nkeji edemede site:

Dr. Zeng

Co-guzobere, onye isi ụlọ ọrụ na-edu ndú; PhD natara na Fudan University na organic onwu. Ihe karịrị afọ itoolu nke ahụmịhe na kemịkal na kemịkalụ ọgwụ; ihe fọrọ nke nta ka ọ bụrụ akwụkwọ nyocha 10 nke ebipụtara na akwụkwọ akụkọ ikikere, yana ihe karịrị akwụkwọ ikike ise nke China.

 

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