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Nkịtị metabolism

Mmetọ ikuku

Mgbasa ozi Ultraviolet

Arụrụ dị arọ nke igwe

Mmetọ Pesticide

Mmetọ Pesticide

 

 

RADICALS & Ọrịa

 

Dị ka ọ na-adịkarị, ihe ndị na-eme ka ihe dị mkpa dị mkpa maka ahụ, mana oke ihe na-akpata free nwere ike ime ka adịghị arụ ọrụ physiological, wee duga nrụgide oxidative na-agbanwe n'ọrịa dị iche iche (akwụkwọ ọgụgụ na-egosi na ndị na-akpata ọrịa bụ isi iyi nke ọrịa dị iche iche).

 

 

 

 

OGOCHI

 

Ahụ anyị enweghị ike ịrụ ọrụ na-enweghị oxygen, na mgbe ọnụ ọgụgụ buru ibu nke ihe ndị na-enweghị onwe ha na-abawanye, ahụ dị n'okpuru nrụgide oxidative ga-eme ka usoro ndozi ahụ ghara ịdapụ na-ewepụ radical free. N’ọnọdụ pụrụ iche, ahụ chọrọ mejupụta antioxidants in vitro iji wepu oke ihe ọkụkụ na-enweghị isi.

 

Ọganihu nke ndị ANTIOXIDANTS

 

 

L-ERGOTHIONEINE – Tdị ỌH NEWR NEW NKE ANY AN NA-EME

 

NGG bụ ihe eke chiral amino-acid antioxidant biosynthesized na ụfọdụ bacteria na fungi. Ọ bụ ihe dị mkpa bioactive nke e jiri mee ihe dị ka onye na-atụgharị egwu, ihe ntanetị na-eme ka ultraviolet ray, onye na-achịkwa mmeghachi omume nke oxydation na cellular bioenergetics, na usoro physiology, wdg
L-Ergothioneine (EGT, ERGO, CAS: 497-30-3), makwaara dị ka (S) -α-Carboxy-2,3-dihydro-N, N, N-trimethyl-2-thioxo-1H-imidazole- Ntan 4-ethanaminium dị n’ime ya, bụ nke Tanret C wepụrụ ya na mbu na 1909, emesia achọpụtakwa n’ime ọbara anụmanụ. EGT dị ọcha bụ kristal na-acha ọcha, na-agbanye mmiri, (etisasịwo 0.9mol / L na okpomọkụ ụlọ). Xchekwa onwe onwe apughi ibia nihe omumu pH ma obu na alkaline siri ike. EGT nwere ike ịdị n'ụdị abụọ isomer - ụdị thiol na ụdị thione, dị ka egosiri n'okpuru:

 

 

 

Mgbanwe

Na uru nke ọtụtụ ọrụ, NGG pụtara ìhè n'etiti ọtụtụ antioxidants ndị ọzọ.

 

 

uru

Site na uru nke ọtụtụ ọrụ, EGT pụtara ìhè n'etiti ọtụtụ ndị ọzọ antioxidants.A bara uru (ma e jiri ya tụnyere glutathione, cysteine ​​wdg):
——EGT dị mfe njupụta na mkpụrụ ndụ ma ịta ahụhụ kwụsie ike karịa antioxidants ndị ọzọ.
——EGT na-arụ ọrụ nke ọma n'ibelata ọnwụ mkpụrụ ndụ nke pyrogallol kpatara.
——EGT tumadi scavenges ROS iji gbochie ọxịdashọn, ebe glutathione na ndị ọzọ na - atụgharị ndị na - enweghị ihe ọ bụla, ya bụ, ndị ọzọ antioxidants scavenge ọxịdashọn ngwaahịa.(1) Oleoylethanolamide (oea) - anwansi anwansi nke ndu gi

AKPARKỌ ANTIOXIDATION

Results: NGG bụ onye na-arụ ọrụ kachasị arụ ọrụ nke free radicals ma e jiri ya tụnyere antioxidants kpochapụwo dịka GSH, uric acid na trolox. Karịsịa, ikike antioxidant kachasị elu nke EGT vs. peroxyl radicals gosipụtara 25% dị elu karịa uru enwetara na ntụpọ antioxidant antioxidant. Ike ntụgharị nke EGT maka hydroxyl radicals bụ 60% dị elu, ma e jiri ya tụnyere uric acid, nke na-anọchite anya ntụpọ antioxidant vs. hydroxyl radicals. N'ikpeazụ, EGT gosipụtara ọrụ antioxidant kachasị elu na-aga n'ihu peroxynitrite, yana ikike ngbachapu 10% karịa nke uric acid.

 

 

 

OGWU NWA OMA

 

EGT nwekwara mmetụta na nhazi nke ike intracellular,

na - eme ka ihe ndị nwere ike ịdọrọ mmadụ,

mee ka nkpuru nwoke ghara idiwanye,

ikpuchi umeji site na mmerụ ahụ,

igbochi mbufụt,

nyocha,

ntụpọ na mmepe.

 

 

Mkpa nke mmepe

A NA-AHU EGT N'IME N'INLU N'ALITE NA IMLỌ

 

Nkuzi

5-10mg kwa otu maka okenye na 2-3 nkeji na-aga n'ihu oriri dị oké mkpa na gị kwa ụbọchị nri.

Ebe e si nweta ya: Li Yiqun, Zhou Nianbo. Ọrụ bayoloji na Ngwa nke EGT [J]. Nchịkwa nri ， 2010，9 （3） ： 26-28.

Edepụtara ihe ndị dị ka ndị a:

Mụaka (afọ 3-11) 0 XNUMX mg / ụbọchị
Ntorobịa (afọ 11-21) ≤30 mg / ụbọchị
Ndị okenye (afọ 21-80) ≤30 mg / ụbọchị

Rịba ama ： 1. Ọgwụ maka ụmụaka na ndị okenye （3 -80 afọ）

           2.Iji maka ụmụ nwanyị dị ime ma ọ bụ ụmụ nwanyị na-enye ara ndụmọdụ.

Isi data: Tetrahedron mgbe ị na-etinye maka US NDI

Data na-atụ aro: 10.5mg / g maka OXIS's ADI (Intakeable Daily Intake).

 

③ EBERE

 

 

Mwepu na ntinye

(1) MB EXP.

Ka ọ dị ugbu a, ụzọ atọ maka mmepụta EGT: njikọ kemịkalụ, eke bio-mmịpụta (tumadi site na mushrooms, anụ ahụ anụ na mmịpụta ọbara), na usoro biosynthesis.

Tụnyere nke EGT mmịpụta ụzọ

(2) NA-EME

EGT nwere ngwa sara mbara na ihe ịchọ mma, nri oriri, ọgwụ, ọgwụgwọ, biomedicine, wdg.

(3) IHE ND OTHER ỌZỌ NA-EME

References

  1. Oleoylethanolamide (oea) - ihe anwansi anwansi nke ndu gi
  2. Anandamide vs cbd: kedu nke ka mma maka ahụike gị? Ihe niile ị chọrọ ịma banyere ha!
  3. Ihe niile ịchọrọ ịma gbasara nicotinamide riboside chloride
  4. Mmeju nke Magnesium l-threonate: uru, onunu ogwu, na ihe ndi ozo
  5. Palmitoylethanolamide (agwa): uru, onunu ogwu, ojiji, mgbakwunye
  6. Top 6 uru uru nke resveratrol Mmeju
  7. Top 5 uru nke ị ofụ phosphatidylserine (ps)
  8. Ihe nlekọta 5 kacha elu na-ewere pyrroloquinoline quinone (pqq)
  9. Ihe kacha mma nootropic nke alpha gpc
  10. Ngwunye kachasị mma nke ịka nká nke nicotinamide mononucleotide (nmn)

 

Nkeji edemede site ： Dr. Zeng

Nkeji edemede site:

Dr. Zeng

Co-guzobere, onye isi ụlọ ọrụ na-edu ndú; PhD natara na Fudan University na organic onwu. Ihe karịrị afọ itoolu nke ahụmịhe na kemịkal na kemịkalụ ọgwụ; ihe fọrọ nke nta ka ọ bụrụ akwụkwọ nyocha 10 nke ebipụtara na akwụkwọ akụkọ ikikere, yana ihe karịrị akwụkwọ ikike ise nke China.

 

ọdịnaya