Echekwala Cofttek

S6 kinase & PKD-1

AZD2014 (1009298-59-2)

AZD2014 bụ onye mmeghe mTOR nke na-eme ihe na IC50 nke 2.8 nM; akwa nhọrọ maka otutu PI3K isoforms (α / β / y / δ).

Achọghị iji ọgwụgwọ eme ihe. Maka nyocha ihe naanị.

CAS: 1009298-59-2 Category

AZD2014 (1009298-59-2) Daha

Vistusertib, nke a makwaara dị ka AZD2014, bụ onye na-adịghị ekwu okwu na-enweghị ihe ọhụụ nke anụ mammal nke rapamycin (mTOR) nwere ike ịnweta ọrụ antineoplastic. mTOR kinase inhibitor AZD2014 na-egbochi ọrụ nke mTOR, nke nwere ike ịkpata ntinye nke apoptosis tumor cell na ọnụ ọgụgụ nke ụbụrụ tumọ cell. mTOR, bụ serine / threonine kinase nke dị n'ọbara dị iche iche, na-arụ ọrụ dị mkpa dị na ala na ụzọ PI3K / Akt / mTOR.

AZD2014 (1009298-59-2) Smmezi

Product Name AZD2014
Mmekọrịta AZD2014, AZD-2014, AZD 2014, Vistusertib
Chemical Aha 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide
Klaasị ọgwụ ọjọọ Antineoplastics
ọcha ≥98% (HPLC)
CAS Number 1009298-59-2
molekụla Fnhazi C25H30N6O3
molekụla Wasatọ 462.54
Nkịtị Monoisotopic 462.23794 g / mol
Nọmba MDL MFCD22628784
InChIKey JUSFANSTBFGBAF-IRXDYDNUSA-N
Usoro InChi InChI=1S/C25H30N6O3/c1-16-14-33-11-9-30(16)23-20-7-8-21(18-5-4-6-19(13-18)24(32)26-3)27-22(20)28-25(29-23)31-10-12-34-15-17(31)2/h4-8,13,16-17H,9-12,14-15H2,1-3H3,(H,26,32)/t16-,17-/m0/s1
SMILES O = C (NC) C1 = CC = CC (C2 = CC = C3C (N4 [[Email na-echebe]H) (C) COCC4) = NC (N5 [[Email na-echebe]H) (C) COCC5) = NC3 = N2) = C1
ụdị ntụ ntụ
Agba Yellow
Sume Soluble na DMSO, ọ bụghị na mmiri
Sịkwa akwa Temp. 0 - 4 C maka mkpirikpi oge (ụbọchị ruo izu), ma ọ bụ -20 C maka ogologo oge (ọnwa)
adị ndụ > Afọ 2 ma ọ bụrụ na echekwara ya nke ọma
njikwa Chebe na ikuku na mmiri
ngwa Vistusertib (AZD2014) bụ onye mmeghe mTOR


=

RIDADR NONH maka ụdị uzo niile

References:

[1]. Huo HZ, Zhou ZY, Wang B, Qin J, Liu WY, Gu Y. Ngosipụta mmebi nke cancer cancer colorectal site na mTORC1 na mTORC2 na-emechi AZD-2014. Obodo Ngwurugwu Biochemys. 2014 Jan 10; 443 (2): 406-12. ma ọ bụ: 10.1016 / j.bbrc.2013.11.099. Epub 2013 Dec 2. PubMed PMID: 24309100.

[2]. Kahn J, Hayman TJ, Jamal M, Rath BH, Kramp T, Camphausen K, Tofilon PJ. Onye na-eme ihe mTORC1 / mTORC2 na-emepụta AZD2014 na-eme ka radiosensitivity nke mkpụrụ ndụ glioblastoma dị ka mkpụrụ ndụ. Neuro Oncol. 2014 Jan; 16 (1): 29-37. a: 10.1093 / neuonc / not139. Epub 2013 Dec 4. PubMed PMID: 24311635; PubMed Central PMCID: PMC3870843.

[3]. Rastogi R, Jiang Z, Ahmad N, Rosati R, Liu Y, Beuret L, Monks R, Charron J, Birnbaum MJ, Samavati L. Rapamycin na-emepụta protein sitere na mitogen (MAP) kinase phosphatase-1 (MKP-1) site na mmalite nke protein kinase B na ụzọ mgbochi-protein kinase kinase. J Biol Chem. 2013 Nov 22; 288 (47): 33966-77. a: 10.1074 / jbc.M113.492702. Epub 2013 Oct 14. PubMed PMID: 24126911; PubMed Central PMCID: PMC3837136.

[4]. Cosimo E, Tarafdar A, Moles MW, Holroyd AK, Malik N, Catherwood MA, Hay J, Dunn KM, Macdonald AM, Guichard SM, O'Rourke DM, Leach MT, Sansom OJ, Cosulich SC, McCaig AM, Michie AM.

Ọrịa Cancer Res. 2018 Dec 17. kpọọ: clincanres.2036.2018. doi: 10.1158 / 1078-0432.CCR-18-2036. [Epub n'ihu mbipụta]

PMID: 30559170

[5]. Pike KG, Malagu K, Hummersone MG, Menear KA, Duggan HM, Gomez S, Martin NM, Ruston L, Pass SL, Pass M. Ịchọpụta nke abụọ mTORC1 na mTORC2 na-emechi: nchọpụta nke AZD8055 na AZD2014. Bioorg Med Chem Lett. 2013 Mar 1; 23 (5): 1212-6. a: 10.1016 / j.bmcl.2013.01.019. Epub 2013 Jan 18. PubMed PMID: 23375793.

1 nyochaa maka AZD2014 (1009298-59-2)

  1. Cofttek -

    Enweghi ahụmahụ dị otú ahụ dị otú ahụ tupu, AZD2014 (1009298-59-2) bụ ịdị ọcha dị elu, ọrụ ahịa dịkwa mma!

Tinye a nyochaa

Na adreesị email gị agaghị bipụtara. Chọrọ ubi na- *