Echekwala Cofttek

S6 kinase & PKD-1

GSK2334470 (1227911-45-6)

GSK2334470 bụ onye edemede PDK1 na IC50 nke ~ 10 nM na ihe nkwụnyeghị mkpụrụ ndụ, na enweghị ọrụ na AGC-kinases.-PDK inhibitor.

Achọghị iji ọgwụgwọ eme ihe. Maka nyocha ihe naanị.

CAS: 1227911-45-6 Category

GSK2334470 (1227911-45-6) Daha

3-Phosphoinositide-dependent protein kinase (PDK1) bụ serine-threonine kinase nke na-arụ ọrụ dị mkpa n'uto ihe na-egosi site na phosphorylating ma na-eme ka otu ìgwè kinases, gụnyere protein kinase (PK) B, PKA, na ụfọdụ ọdịdị nke PKC. GSK2334470 bụ onye na-emechi nke PDK1 (IC50 = ~ 10 nM) na ọbụnadị na 100-n'ogige dị elu karịa emetụta ọrụ nke 93 ndị ọzọ protein kinases, tinyere nke nke 13 nwere njikọ chiri anya AGC kinase ezinụlọ. Na mkpụrụ ndụ HEK293, 30 nM - 1 μM GSK2334470 na-egbochi T-loop na phosphorylation na mmalite nke SGK, S6K1, na RSK, yana mmalite nke Akt. GSK2334470 gwakwara T-loop phosphorylation na mmalite nke akt. GSK2334470 ga-abụ ngwá ọrụ bara uru iji depụta ọrụ PDK1 na usoro nhazi.

GSK2334470 (1227911-45-6) Smmezi

Product Name GSK2334470
Mmekọrịta GSK2334470; GSK 2334470; GSK-2334470
Chemical Aha (3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide
Klaasị ọgwụ ọjọọ 3-phosphoinositide-dependent protein kinase (PDK1) inhibitor
ọcha ≥98% (HPLC)
CAS Number 1227911-45-6
molekụla Fnhazi C25H34N8O
molekụla Wasatọ 462.6
Nkịtị Monoisotopic 462.28556 g / mol
Nọmba MDL MFCD16660191
InChIKey QLPHOXTXAKOFMU-WBVHZDCISA-N
Usoro InChi InChI=1S/C25H34N8O/c1-15-8-9-17(24(34)28-18-6-4-3-5-7-18)14-33(15)22-13-20(29-25(27-2)30-22)16-10-11-19-21(12-16)31-32-23(19)26/h10-13,15,17-18H,3-9,14H2,1-2H3,(H,28,34)(H3,26,31,32)(H,27,29,30)/t15-,17+/m1/s1
SMILES NC1 = NNC2 = CC (C3 = CC (N4C [[Email na-echebe]H (C (NC5CCCCC5) = O) CC [[Email na-echebe]] 4C) = NC (NC) = N3) = CC = C21
ụdị A crystalline siri ike
Agba White
Sume Soluble na DMSO, ọ bụghị na mmiri
Sịkwa akwa Temp. Mmiri, ọchịchịrị na 0 - 4 C maka obere oge (ụbọchị ruo izu) ma ọ bụ -20 C maka ogologo oge (ọnwa ruo afọ).
adị ndụ > Afọ 2 ma ọ bụrụ na echekwara ya nke ọma
njikwa Chebe na ikuku na mmiri
ngwa Ihe nwere ike imepụta protein 3-phosphoinositide-dependent protein kinase (PDK1)


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RIDADR NONH maka ụdị uzo niile

References:

[1]. Knight ZA. Maka onye na-eme ihe PDK1, ihe dị mkpa bụ mkpụrụ. Biochem J. 2011 Jan 15; 433 (2): e1-2. a: 10.1042 / BJ20102038. PubMed PMID: 21175429.

[2]. Najafov A, Sommer EM, Axten JM, Deyoung MP, Alessi DR. Ihe ngosi nke GSK2334470, akwukwo ukwu na onye nkiti nke PDK1. Biochem J. 2011 Jan 15; 433 (2): 357-69. a: 10.1042 / BJ20101732. PubMed PMID: 21087210.

[3]. Najafov, A., Sommer, EM, Axten, JM, et al. Nkọwa nke GSK2334470, akwụkwọ edemede na onye nkatọ nke PDK1 Biochemistry Journal433 (2), 357-369 (2011).

[4] .Gutiérrez-Martínez; Rubio; Piedra-Quintero; Lopez-Mendez; Serrano; Reyes-Maldonado; Salinas-Lara; (...) Villegas-Sepúlveda; Nava - Oncology Translation 2019 vol. 12 # 1 p. 24 - 35

[5]. Li, Dong-Dong; Meng, Xiang-Feng; Wang, Qiang; Yu, Pan; Zhao, Lin-Guo; Zhang, Zheng-Ping; Wang, Zhen-Zhong; Xiao, Wei - Journal of Graphics and Modeling 2018 vol. 79 p. 81 - 87

1 nyochaa maka GSK2334470 (1227911-45-6)

  1. Cofttek -

    Ọ dịghị mgbe ọ bụla ị nwere ahụmahụ dị otú ahụ na mbụ, GSK2334470 (1227911-45-6) bụ ịdị ọcha dị elu, yana ọrụ ahịa dị ezigbo mma!

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