Echekwala Cofttek

S6 kinase & PKD-1

kb NB 142-70 NB (1233533-04-4)

kb NB 142-70 bụ onye na-emepụta protein kinase D (PKD) ahọpụtara (ụkpụrụ IC50 bụ 28.3, 58.7 na 53.2 nM maka PKD1, 2 na 3 n'otu n'otu) .- PKD inhibitor.

Achọghị iji ọgwụgwọ eme ihe. Maka nyocha ihe naanị.

CAS: 1233533-04-4 Category

kb NB 142-70 NB (1233533-04-4) Daha

kb NB 142-70 bụ onye na-emepụta protein protein kinase D (PKD) ahọpụtara (ụkpụrụ IC50 bụ 28.3, 58.7 na 53.2 nM maka PKD1, 2 na 3 n'otu n'otu) .kb NB 142-70 bụ onye na-egbochi protein protein kinase D (PKD) Ụkpụrụ IC50 bụ 28.3, 58.7 na 53.2 nM maka PKD1, 2 na 3 n'otu n'otu. kb NB 142-70 na-egbochi mwepụ nke ọnya nke mkpụrụ ndụ epithelial. PKD1, onye a kacha mụọ nke ezinụlọ PKD, na-etinye aka n'usoro iwu nke usoro ihe omimi dị iche iche, gụnyere mgbagharị mgbaàmà, ntinye mkpụrụ ndụ na ọdịiche dị iche iche, ịzụ ahịa akpụkpọ anụ, ikpenye hormones, usoro nkwụsịtụ, hypertrophic cardiac, angiogenesis, na cancer .

kb NB 142-70 NB (1233533-04-4) Smmezi

Product Name kb NB 142-70
Mmekọrịta kb NB 142-70; kb NB142-70; kb NB-142-70.
Chemical Aha 9-hydroxy-3,4-dihydrobenzo[4,5]thieno[2,3-f][1,4]thiazepin-5(2H)-one
Klaasị ọgwụ ọjọọ Onye mmechi PKD
ọcha ≥98% (HPLC)
CAS Number 1233533-04-4
molekụla Fnhazi C11H9NO2S2
molekụla Wasatọ 251.00747
Nkịtị Monoisotopic 251.32 g / mol
Nọmba MDL MFCD18086915
InChIKey DHUAGGSHTKPOHU-UHFFFAOYSA-N
Usoro InChi InChI=1S/C11H9NO2S2/c13-6-1-2-8-7(5-6)9-10(16-8)11(14)12-3-4-15-9/h1-2,5,13H,3-4H2,(H,12,14)
SMILES O=C1NCCSC2=C1SC3=CC=C(O)C=C32
ụdị ntụ ntụ
Agba N / A
Sume Soluble na DMSO, ọ bụghị na mmiri
Sịkwa akwa Temp. 0 - 4 C maka mkpirikpi oge (ụbọchị ruo izu), ma ọ bụ -20 C maka ogologo oge (ọnwa).
adị ndụ > Afọ 2 ma ọ bụrụ na echekwara ya nke ọma
njikwa Chebe na ikuku na mmiri
ngwa Onye mmegide PKD họpụtara


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RIDADR NONH maka ụdị uzo niile

References:

[1]. Young SH, Rozengurt N, Sinnett-Smith J, Rozengurt E. Ntinye protin protein kinase D1 na-akwalite mpụga nke mkpụrụ ndụ epithelial eriri afọ. M J Physiol Gastrointest Ọkpụkpụ Nkịtị. 2012 Aug 1; 303 (3): G356-66. a: 10.1152 / ajpgi.00025.2012. Epub 2012 Ka 17. PubMed PMID: 22595992; PubMed Central PMCID: PMC3423107.

[2]. Yang, Chun; Ren, Qian; Qu, Youge; Zhang, Ji-Chun; Ma, Min; Dong, Chao; Hashimoto, Kenji - 2018 Vol. 83 # 1 p. 18 - 28

[1]. Kawata, Takahito; Tada, Kohei; Kobayashi, Masayuki; Sakamoto, Takashi; Takiuchi, Yoko; Iwai, Fumie; Sakurada, Maki; Sato, Hironori; Takaori-Kondo, Akifumi - Ọrịa Cancer 2018 vol. 109 # 1 p. 103 - 111

[4]. Na Y, Wang L, Zhang J, Pang Z, Liu Q, Du J. PKD1 na-agbadata na ọrịa cancer na-abụghị obere cell ma na-akwado mgbasa ozi nzaghachi nke mTORC1-S6K1 axis na azịza nke phorbol ester. Int J Biochem Cell Biol. 2015 Mar; 60: 34-42. dị: 10.1016 / j.biocel.2014.12.018. Epub 2015 Jan 9. PubMed PMID: 25578563.

[5]. Li, Dong-Dong; Meng, Xiang-Feng; Wang, Qiang; Yu, Pan; Zhao, Lin-Guo; Zhang, Zheng-Ping; Wang, Zhen-Zhong; Xiao, Wei - Journal of Graphics and Modeling 2018 vol. 79 p. 81 - 87

1 nyochaa maka kb NB 142-70 NB (1233533-04-4)

  1. Cofttek -

    Ọ dịghị mgbe ọ bụla ị nwere ahụmahụ dị otú ahụ na mbụ, kb NB 142-70 (1233533-04-4) bụ ịdị ọcha dị elu, nakwa ọrụ ahịa dị mma!

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