Echekwala Cofttek

S6 kinase & PKD-1

GSK2982772 (1622848-92-3)

GSK2982772 bụ onye ntanetị nwere ike ịhọrọ ma na-ahọrọ ihe na-eme ka 1 (RIP1) na-ahụ maka ọgwụgwọ ọrịa inflammatory.

Achọghị iji ọgwụgwọ eme ihe. Maka nyocha ihe naanị.

CAS: 1622848-92-3 Category

GSK2982772 (1622848-92-3) Daha:

GSK2982772 bụ onye na-agba ọsọ RIP1 dị egwu na ATP na IC50 nke 16 nM. GSK2982772 bụ onye na-anabata ma na-ahọrọ ihe ntanetị bụ 1 (RIP1) Na-ahụ Maka Ọrịa Na-ahụ Maka Nlekọta Ọrịa Inflammatory. GSK2982772 bụ, ugbu a na usoro 2a ọmụmụ gbasara ọmụmụ psoriasis, ọrịa ogbu na nkwonkwo, na ulcerative colitis. GSK2982772 na-ejikọta RIP1 n'ụzọ dị mma ma nwee ezigbo ọrụ na igbochi ọtụtụ nzaghachi cellular TNF. RIP1 apụtawo dị ka ihe dị mkpa upstream kinase nke egosipụtara iji chịkwaa mbufụt site na arụmọrụ abụọ na mmekorita ọrụ ụfọdụ.

GSK2982772 (1622848-92-3) Smmezi:

Product Name GSK2982772
Mmekọrịta GSK2982772; GSK-2982772; GSK 2982772.
Chemical Aha (S)-5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b]-[1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide
Klaasị ọgwụ ọjọọ ATP asọmpi RIP1 inhibitor
ọcha ≥98% (HPLC)
CAS Number 1622848-92-3
molekụla Fnhazi C20H19N5O3
molekụla Wasatọ 377.404
Nkịtị Monoisotopic 377.1488 g / mol
Nọmba MDL MFCD09953122
InChIKey LYPAFUINURXJSG-AWEZNQCLSA-N
Usoro InChi InChI=1S/C20H19N5O3/c1-25-15-9-5-6-10-16(15)28-12-14(20(25)27)21-19(26)18-22-17(23-24-18)11-13-7-3-2-4-8-13/h2-10,14H,11-12H2,1H3,(H,21,26)(H,22,23,24)/t14-/m0/s1
SMILES O = C (C1 = NN = C (CC2 = CC = CC = C2) N1) N [[Email na-echebe]3C (N (C) C4 = CC = CC = C4OC3) = O
ụdị ntụ ntụ
Agba Yellow
Sume Soluble na DMSO.
Sịkwa akwa Temp. Mmiri, ọchịchịrị na 0 - 4 C maka obere oge (ụbọchị ruo izu) ma ọ bụ -20 C maka ogologo oge (ọnwa ruo afọ).
adị ndụ > Afọ 2 ma ọ bụrụ na echekwara ya nke ọma
njikwa Chebe na ikuku na mmiri
ngwa Onye ATP na-agba ọsọ RIP1


=

RIDADR NONH maka ụdị uzo niile

References:

[1]. Weisel K, Scott NE, Tompson DJ, Votta BJ, Madhavan S, Povey K, Wolstenholme A, Simeoni M, Rudo T, Richards-Peterson L, Sahota T, Wang JG, Lich J, Finger J, Verticelli A, Reilly M, Gough PJ, Harris PA, Bertin J, Wang ML.

[2]. Jinger JN, Brusq JM, Campobasso N, Cook MN, Deutsch J, Haag H, Harris PA, Jenkins EL, Joglekar D, Lich JD, Maguire S, Nagilla R, Rivera EJ, Sun H, Votta BJ, Bertin J, Gough PJ . Na ọgwụ Pharmacol Respect. 2017 Dec; 5 (6). doi: 10.1002 / prp2.377 PMID: 29226625

[3]. Weisel K, Scott NE, Tompson DJ, Votta BJ, Madhavan S, Povey K, Wolstenholme A, Simeoni M, Rudo T, Richards-Peterson L, Sahota T, Wang JG, Lich J, Finger J, Verticelli A, Reilly M, Gough PJ, Harris PA, Bertin J, Wang ML. Na ọgwụ Pharmacol Respect. 2017 Dec; 5 (6). a: 10.1002 / prp2.365. PMID: 29226626

[4] .Gutiérrez-Martínez; Rubio; Piedra-Quintero; Lopez-Mendez; Serrano; Reyes-Maldonado; Salinas-Lara; Villegas-Sepúlveda; Nava - Oncology Translation 2019 vol. 12 # 1 p. 24 - 35

[5]. Harris PA, Berger SB, Jeong JU, Nagilla R, Bandyopadhyay D, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Eidam PM, Finger JN, Hoffman SJ, Kang J, Kasparcova V, Eze BW, Lehr R , Lan Y, Leister LK, Lich JD, MacDonald TT, Miller NA, Ouellette MT, Pao CS, Rahman A, Reilly MA, Rendina AR, Rivera EJ, Schaeffer MC, Sehon CA, Singhaus RR, Sun HH, Swift BA, Totoritis Rd, Vossenkämper A, Ward P, Wisnoski DD, Zhang D, Marquis RW, Gough PJ, Bertin J. Nchọpụta nke 1 (RIP1) Na-ahụ Maka Nlekọta Na-ahụ Maka Ihe Nlekọta (GSK2982772) maka Ngwọta nke Inflammatory Ọrịa. J Med Chem. 2017 Feb 10. a: 10.1021 / acs.jmedchem.6b01751. [Epub n'ihu mbipụta] PubMed PMID: 28151659.

1 nyochaa maka GSK2982772 (1622848-92-3)

  1. Cofttek -

    Ọ dịghị mgbe ọ bụla ị nwere ahụmahụ dị otú ahụ na mbụ, GSK2982772 (1622848-92-3) bụ ịdị ọcha dị elu, yana ọrụ ahịa dị ezigbo mma!

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