Echekwala Cofttek

S6 kinase & PKD-1

CHIR-99021 (CT99021) (252917-06-9)

CHIR-99021 HCl (CT99021) bụ hydrochloride nke CHIR-99021, nke bụ onye nkwụnye GSK-3α / β na IC50 nke 10 nM / 6.7 nM; CHIR-99021 gosipụtara karịa 500-fold selectivity maka GSK-3 na ezigbo homogene Cdc2 na ERK2.

Achọghị iji ọgwụgwọ eme ihe. Maka nyocha ihe naanị.

CAS: 252917-06-9 Category

CHIR-99021 (CT99021) (252917-06-9) Daha

CHIR 99021 bụ otu n'ime klas nke aminopyrimidines bụ 2-aminopyrimidine nọ n'ọnọdụ N2, 5 na 6 site na 5-cyanopyridin-2-yl) ethyl, 4-methylimidazol-2-yl na 2,4-dichlorophenyl n'otu n'otu. O nwere ọrụ dịka EC 2.7.11.26 (tau-protein kinase) inhibitor. Ọ bụ otu n'ime imidazoles, dichlorobenzene, aminopyrimidine, aminopyridine, cyanopyridine, ụlọ ọrụ amino abụọ na diamine.

CHIR-99021 (CT99021) (252917-06-9) Smmezi

Product Name CHIR-99021 (CT99021) HCl
Mmekọrịta CHIR-911; CHIR911; CHIR 911; CT-99021; CT99021; CT 99021; CHIR-73911; CHIR73911; CHIR 73911; GSK 3 inhibitor XVI; GSK 3IXV; CHIR99021; CHIR 99021;
Chemical Aha C6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile
Klaasị ọgwụ ọjọọ Onye mmechi
ọcha ≥98% site HPLC
CAS Number 252917-06-9
molekụla Fnhazi C22H18Cl2N8
molekụla Wasatọ 465.35
Nkịtị Monoisotopic 465.35 g / mol
Nọmba MDL MFCD11846251
InChIKey AQGNHMOJWBZFQQ-UHFFFAOYSA-N
Usoro InChi InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
SMILES N#CC1=CN=C(NCCNC2=NC=C(C3=NC(C)=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2)C=C1
ụdị Azu uzuzu
Agba acha ọcha na-acha aja aja
Sume ≥25.1mg / mL na DMSO
Sịkwa akwa Temp. Chekwaa ma ọ bụ n'okpuru -20 Celsius C. Ụdị siri ike dịgide ma ọ dịkarịa ala ọnwa 12 site na ụbọchị nke natara, mgbe echekwara dị ka a gwara ya. Echekwala ihe ngwọta maka ihe karịrị otu ụbọchị.
adị ndụ > Afọ 5 ma ọ bụrụ na echekwara ya nke ọma
njikwa Chebe na ikuku na mmiri
ngwa Onye na-egbochi GSK-3A / β


=

RIDADR NONH maka ụdị uzo niile

References:

[1]. Wu Y, Liu F, Liu Y, Liu X, Ai Z, Guo Z, Zhang Y. GHK3 mmechi CHIR99021 na 6-bromoindirubin-3'-oxime na-egbochi microRNA maturation n'ime mkpụrụ ndụ mkpụrụ ndụ nke mkpụrụ ndụ nke ẹmbrayo. Sci Rep. 2015 Mar 2; 5: 8666. a: 10.1038 / srep08666. PubMed PMID: 25727520; PubMed Central PMCID: PMC4345320.

[2]. Li C, Zhang S, Lu Y, Zhang Y, Wang E, Cui Z. Ọrụ nke Notch3 na proliferation cell na apoptosis nke CHIR99021 nọ na NSCLC cell sụgharịrị: njikọ njikọ n'etiti ụzọ Wnt na Notch. Ejiri otu. 2013 Dec 18; 8 (12): e84659. a: 10.1371 / journal.pone.0084659. 2013 eCollection. PubMed PMID: 24367688; PubMed Central PMCID: PMC3867546.

[3]. Aha Z, Shao J, Wu Y, Yu M, Du J, Shi X, Shi X, Zhang Y, Guo Z. CHIR99021 na-eme ka okwu Klf4 mewanyewanye site na β-Catenin Signing na miR-7a Iwu na J1 Mouse Embryonic Stem Cells. Ejiri otu. 2016 Mar 3; 11 (3): e0150936. a: 10.1371 / journal.pone.0150936. 2016 eCollection. PubMed PMID: 26938105; PubMed Central PMCID: PMC4777400.

[4]. Qin H, Hejna M, Liu Y, Percharde M, Wossidlo M, Blouin L, Durruthy-Durruthy J, Wong P, Qi Z, Yu J, Qi LS, Sebastiano V, Song JS, Ramalho-Santos M. YAP Pluripotency. Nyocha Cell 2016 Mar 15; 14 (10): 2301-12. a: 10.1016 / j.celrep.2016.02.036. Epub 2016 Mar 3. PubMed PMID: 26947063; PubMed Central PMCID: PMC4807727.

[5]. Roccio M, Hahnewald S, Perny M, Senn P. Nweghachi nke mkpụrụ ndụ nke mkpụrụ ndụ cochlear progenitor na anụ ugbo FUCCI site na GSK3 obere inhibitor mole. Sci Rep. 2015 Dec 8; 5: 17886. a: 10.1038 / srep17886. PubMed PMID: 26643939; PubMed Central PMCID: PMC4672274.

1 nyochaa maka CHIR-99021 (CT99021) (252917-06-9)

  1. Cofttek -

    Ọ dịghị mgbe ị nwere ahụmahụ dị otú ahụ dị mkpa tupu oge ahụ, CHIR-99021 (CT99021) (252917-06-9) bụ ịdị ọcha dị elu, ọrụ ahịa dịkwa mma!

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