Echekwala Cofttek

S6 kinase & PKD-1

MLS-2052 (BIO) (667463-62-9)

BIO (6-bromoindirubin-3'-oxime) bụ onye na-emechi GSK-3 na IC50 nke 5 nM maka GSK-3α / β, na-egosi> 16-fold selectivity over CDK5, nakwa onye inhibitor pan-JAK ...

Achọghị iji ọgwụgwọ eme ihe. Maka nyocha ihe naanị.

CAS: 667463-62-9 Category

MLS-2052 (BIO) (667463-62-9) Daha:

MLS-2052, oge a maara dịka BIO na GSK3 Inhibitor IX, bụ ụdị mkpụrụ ndụ (indirubin) nke na-arụ ọrụ na-arụ ọrụ, nke na-eme ihe dị egwu, nke nwere ike ịhọrọ, na onye ATP-mgbagwoju anya nke GSK3α / β (IC50 = 5 nM ).

MLS-2052 (BIO) (667463-62-9) Smmezi:

Product Name MLS-2052 (BIO)
Mmekọrịta BIO; GSK3 onye nnochi IX; MLS 2052; MLS-2052; MLS2052.
Chemical Aha 6-Bromoindirubin-3'-oxime
Klaasị ọgwụ ọjọọ Antineoplastics
ọcha ≥98% (HPLC)
CAS Number 667463-62-9
molekụla Fnhazi C16H10BrN3O2
molekụla Wasatọ 356.179
Nkịtị Monoisotopic 354.9956 g / mol
Nọmba MDL MFCD08705318
InChIKey DDLZLOKCJHBUHD-WAVHTBQISA-N
Usoro InChi InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+
SMILES O=C(/C1=C2NC3=C(C\2=N/O)C=CC=C3)NC4=C1C=CC(Br)=C4
ụdị ntụ ntụ
Agba acha uhie uhie
Sume Soluble na DMSO, ọ bụghị nke nwere mmiri
Sịkwa akwa Temp. 0 - 4 C maka mkpirikpi oge (ụbọchị ruo izu), ma ọ bụ -20 C maka ogologo oge (ọnwa)
adị ndụ > Afọ 2 ma ọ bụrụ na echekwara ya nke ọma
njikwa Chebe na ikuku na mmiri
ngwa MLS-2052, oge a na-akpọ BIO na GSK3 Inhibitor IX


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RIDADR NONH maka ụdị uzo niile

References:

[1]. Meijer, L., Skaltsounis, AL, Magiatis, P., et al. GSK-3-ndị na-egbochi ndị na-emechi emepụta sitere na odo odo odo odo indirubins. Chem. Biol. 10 (12), 1255-1266 (2003).

[2]. Polychronopoulos, P., Magiatis, P., Skaltsounis, AL, et al. Ebumnuche maka usoro nke indirubins dịka ndị na-eme ihe na-edozi glycogen synthase kinase-3 na kincy cyclin. J. Med. Chem. 47 (4), 935-946 (2004).

[3]. Sato, N., Meijer, L., Skaltsounis, L., et al. Na-emezi ihe dị na mkpụrụ ndụ nke mkpụrụ ndụ embryonic na ụmụ mmadụ na-emegharị site na ịmalite nke mgbaàmà Wnt site na GSK-3. 10 (1) Medicine Nature, 55-63 (2004).

[4]. Tseng, AS, Engel, FB, na Keating, MT Onye GSK-3 na-emechi ihe na-eme ka BIO na-akwalite mmụba na cardiomyocytes mammal. 13, 957-963 (2006).

[5] .Phosphatase PP2A na ndị na - agbasa mgbasa ozi na - emepụta ihe ndị na - emepụta ihe na - ewepụtakwa centrosomes n'oge mpụga mota. Enos SJ, Dressler M, Gomes BF, Hyman AA, Woodruff JB. Open Open. 2018 Jan 12; 7 (1). kpọọ: bio029777. a: 10.1242 / bio.029777. PMID: 29222174.

1 nyochaa maka MLS-2052 (BIO) (667463-62-9)

  1. Cofttek -

    Ọ dịghị mgbe ị nwere ahụmahụ dị otú ahụ na mbụ, MLS-2052 (BIO) (667463-62-9) bụ ịdị ọcha dị elu, ọrụ ahịa dịkwa mma!

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