Echekwala Cofttek

S6 kinase & PKD-1

BX-912 (702674-56-4)

BX912 bụ onye nwere ike ịmepụta PDK1 na IC50 nke 12 nM. BX912 blocks PDK1 / Akt na-egosi na mkpụrụ ndụ tumo ma na-egbochi njigide na-arịwanye elu nke ụbụrụ tumor (dịka sel PC-3) na omenala ma ọ bụ induces apoptosis.

Achọghị iji ọgwụgwọ eme ihe. Maka nyocha ihe naanị.

CAS: 702674-56-4 Category

BX-912 (702674-56-4) Daha:

3-Phosphoinositide-protein protein protein (PDK1) bụ serine-threonine kinase nke phosphorylates ma mee ka ọtụtụ kinases ndị ọzọ, gụnyere protein kinase (PK) B, PKA, na ụfọdụ ọdịdị nke PKC.1 BX-912 bụ ike, ATP-asọmpi na-eme ihe ike nke PDK1 (IC50 = 26 nM). Ọ na-adịchaghị mma igbochi otu syine-threonine kinases.BX-912 metụtara ya iji nyochaa ọrụ nke PDK1 na mmeghasị kinase na ndụ lanarị.

BX-912 (702674-56-4) Smmezi:

Product Name BX-912
Mmekọrịta BX912; BX 912; BX912
Chemical Aha N-(3-((4-((2-(1H-imidazol-4-yl)ethyl)amino)-5-bromopyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamide
Klaasị ọgwụ ọjọọ PDK1 na-emechi ihe
ọcha ≥98% (HPLC)
CAS Number 702674-56-4
molekụla Fnhazi C20H23BrN8O
molekụla Wasatọ 471.35
Nkịtị Monoisotopic 470.118 g / mol
Nọmba MDL MFCD10565925
InChIKey DMMILYKXNCVKOJ-UHFFFAOYSA-N
Usoro InChi InChI=1S/C20H23BrN8O/c21-17-12-24-19(28-18(17)23-7-6-16-11-22-13-25-16)26-14-4-3-5-15(10-14)27-20(30)29-8-1-2-9-29/h3-5,10-13H,1-2,6-9H2,(H,22,25)(H,27,30)(H2,23,24,26,28)
SMILES O=C(N1CCCC1)NC2=CC=CC(NC3=NC=C(Br)C(NCCC4=CNC=N4)=N3)=C2
ụdị ntụ ntụ
Agba White siri ike
Sume Soluble na DMSO (93 mg / mL na 25 Celsius C), mmiri (<1 mg / mL na 25 Celsius C), na ethanol (3 mg / mL na 25 ° C).
Sịkwa akwa Temp. Mmiri, ọchịchịrị na 0 - 4 C maka obere oge (ụbọchị ruo izu) ma ọ bụ -20 C maka ogologo oge (ọnwa ruo afọ).
adị ndụ > Afọ 2 ma ọ bụrụ na echekwara ya nke ọma
njikwa Chebe na ikuku na mmiri
ngwa PDK1 na-emechi ihe


=

RIDADR NONH maka ụdị uzo niile

References:

[1]. Mashukova A, Forteza R, Wald FA, Salas PJ. PDK1 na apical signalomes signalsomes na-ekere òkè na nnapụta nke polarity mgbagwoju atypical PKC site n'etiti filaments ke nsia epithel. Cell Bio Bio. 2012 May; 23 (9): 1664-74. Epub 2012 Mar 7. PubMed PMID: 22398726; PubMed Central PMCID: PMC3338434.

[2]. Feldman, RI, Wu, JM, Polokoff, MA, et al. Obere ihe omuma ndi mmadu nke 3-phosphoinositide-dependent kinase-1 The Journal of Biological Chemisty 280 (20), 19867-19874 (2005).

[3]. Kloo, B., Nagel, D., Pfeifer, M., et al. Ọrụ dị mkpirikpi nke PI3K na-egosi maka ntanarị NF-κB na mpaghara nke B-cell-arụ ọrụ ka ọ na-ekesa nnukwu mkpụrụ ndụ lymphoma B-cell Ụlọ akwụkwọ nke National Academy of Sciences nke United States of America 108 (1), 272-277 (2011).

[4]. Mashukova, A., Forteza, R., Wald, FA, et al. PDK1 na apical signosomes signalsomes na-ekere òkè napụta nke PKC atypical nke dị n'etiti polaity site na filaments dị n'etiti eriri afọ nke mpempe akwụkwọ biology nke Cell 23 (9), 1664-1674 (2012).

[5]. Shibata, E., Kanno, T., Tsuchiya, A., et al. Acids free fatty achoputa protein tyrosine phosphatase 1B ma gbalite Akt Cell Physiology na Biochemistry32 (4), 871-879 (2013).

1 nyochaa maka BX-912 (702674-56-4)

  1. Cofttek -

    Ọ dịghị mgbe ị nwere ahụmahụ dị otú ahụ dị na mbụ, BX-912 (702674-56-4) bụ ịdị ọcha dị elu, yana ọrụ ahịa dị ezigbo mma!

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