Echekwala Cofttek

S6 kinase & PKD-1

BX-795 (702675-74-9)

BX795 bụ onye na-eme ihe ngosi PDK1. BX795 na-ehichapụ MARK1, MARK2, MARK4, NUAK1.

Achọghị iji ọgwụgwọ eme ihe. Maka nyocha ihe naanị.

CAS: 702675-74-9 Category

BX-795 (702675-74-9) Daha:

BX-795 bụ nke e ji mee ihe na mbido nke 3-phosphoinositide-dependent kinase-1. Ihe omumu ndi ozo na BX-795 egosiputa na ihe omuma ahu bu onye na-adi ike nke IKKe na TBK1 nke a mara iji megharia okwu nke interferons site na phosphorylation nke 3 (IRF3).

BX-795 na-asọmpi maka ATP (adenosine triphosphate) n'akpa uwe nke 3-phosphoinositide-dependent kinase-1 (PDK1) na mkpụrụ ya ATP. Mgbagwoju nke vitamin na-egosi na BX-795 nwere ike imebi Unc-51 (serine / threonine-protein kinase) -like autophagy activating kinase (ULK1).

BX-795 (702675-74-9) Smmezi:

Product Name BX-795
Mmekọrịta BX-795; BX 795; BX795.
Chemical Aha N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
Klaasị ọgwụ ọjọọ A ike PDK1 inhibitor
ọcha ≥98% (HPLC)
CAS Number 702675-74-9
molekụla Fnhazi C23H26IN7O2S
molekụla Wasatọ 591.5
Nkịtị Monoisotopic 591.5 g / mol
Nọmba MDL MFCD26406408
InChIKey VAVXGGRQQJZYBL-UHFFFAOYSA-N
Usoro InChi InChI=1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30)
SMILES O=C(N1CCCC1)NC2=CC=CC(NC3=NC=C(I)C(NCCCNC(C4=CC=CS4)=O)=N3)=C2
ụdị A crystalline siri ike
Agba White na-acha aja aja
Sume Soluble na DMSO, ọ bụghị na mmiri
Sịkwa akwa Temp. Mmiri, ọchịchịrị na 0 - 4 C maka obere oge (ụbọchị ruo izu) ma ọ bụ -20 C maka ogologo oge (ọnwa ruo afọ).
adị ndụ > Afọ 2 ma ọ bụrụ na echekwara ya nke ọma
njikwa Chebe na ikuku na mmiri
ngwa Ejirila BX-795 hydrochloride na-amụ banyere mmetụta nke nkwụsị nke kinase na njigide ihe odide transferenuses (HERVs) nke mmadụ.


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RIDADR NONH maka ụdị uzo niile

References:

[1]. Miyabe H, Hyodo M, Nakamura T, Sato Y, Hayakawa Y, Harashima H. ​​Otu nnyefe ọhụrụ adjuvant nke 'cyclic di-GMP / YSK05 liposome' maka cancer immunotherapy. J Control Release. 2014 Jun 28; 184: 20-7. dị: 10.1016 / j.jconrel.2014.04.004. Epub 2014 Apr 13. PubMed PMID: 24727060.

[2] .Parsons KS, Hsu AC, Wark PA. TLR3 na MDA5 na-egosi, ọ bụ ezie na ọ bụghị nkwupụta, enwere ike na mkpụrụ ndụ asthmatic epithelial na nzaghachi nye ọrịa rhinovirus. Ọrịa Na-ahụ Maka Ọrịa Ala. 2014 Jan; 44 (1): 91-101. a: 10.1111 / cea.12218. PubMed PMID: 24131248.

[3] .Awe JP, Crespo AV, Li Y, Kiledjian M, Byrne JA. BAY11 na-eme ka nkwupụta mRNA sụgharịrị sịntaktị dị na mkpụrụ ndụ akpụkpọ anụ mmadụ. Sistem Na-eme Ka Ahụ Dị Nso. 4 Feb 2013; 6 (4): 1. a: 15 / scrt10.1186. PubMed PMID: 163; PubMed Central PMCID: PMC23388106.

[4] .Tamgüney, T., Zhang, C., Fiedler, D., et al. Nyocha nke 3-phosphoinositide-dependent kinase-1 na-arụ ọrụ na mkpụrụ ndụ ES sel 314 (11-12), 2299-2312 (2008).

[5]. Feldman, RI, Wu, JM, Polokoff, MA, et al. Obere ihe omuma ndi mmadu nke 3-phosphoinositide-dependent kinase-1 The Journal of Biological Chemisty 280 (20), 19867-19874 (2005).

1 nyochaa maka BX-795 (702675-74-9)

  1. Cofttek -

    Ọ dịghị mgbe ị nwere ahụmahụ dị otú ahụ dị na mbụ, BX-795 (702675-74-9) bụ ịdị ọcha dị elu, yana ọrụ ahịa dị ezigbo mma!

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