Adelmidrol (1675-66-7)

Adelmidrol Smmezi

Kedu ihe bụ Adelmidrol (1675-66-7)?

Adelmidrol bụ semisynthetic diethanolamide sitere na azelaic acid, ma nwee usoro kemịkalụ symmetrical. E kewara ya dị ka amide, ma yie palmitoylethanolamide, ụmụ irighiri ihe nne na nna na klas ALIAmide nke ọgwụ. ALIAmides bụ otu nke abuba Mwepụta nwere cannabimimetic Njirimara nke nwere mgbochi mkpali na analgesic mmetụta na-eche na ọ na-eme ihe site na ibelata mast cell ịgbalite. Adelmidrol bụ ethanolamide na-egbochi mkpali nke sitere na azelaic acid.

Adelmidrol (1675-66-7) uru

Adelmidrol bụ ihe sintetịt sitere na azelaic acid, acid dicarboxylic juru eju na-emekarị, nke a na-ahụ n'ụfọdụ mkpụrụ osisi dum yana n'ọkwa dị na ahụ mmadụ. Kemịkalụ, ademidrol bụ N, N-bis (2-hydroxyethyl) na-abụghị anedamide na ọ bụ amphiphilic ma ọ bụ amphipathic compound, nwere ma hydrophilic na hydrophobic Njirimara, na-akwado ya solubility ma na aqueous na organic media. Adelmidrol sitere na ezinụlọ aliamide, otu ụdị fatty acid nwere cannabimimetic, nwere ike ịchịkwa hyperreactivity mast cell (MC) n'ọtụtụ ọnọdụ pathophysiological na pathological. Ụzọ NF-κB pro-inflammatory na-ebelata nke ọma site na ọgwụgwọ na adelmidrol. Mmetụta mgbochi mkpali nke adelmidrol pụtara na ọ metụtara na PPAR-gamma ịgbalite. Adelmidrol na-arụ ọrụ nke ọma maka ọrịa akpụkpọ ahụ na-egbu egbu ma nwee ike gbanwee nzaghachi mkpali na keratinocytes mmadụ. Nchikota hyaluronic acid na adelmidrol na-eme ka ihe mgbaàmà nke ọrịa ogbu na nkwonkwo na-ebute site na monosodium iodoacetate.

Adelmidrol (1675-66-7) ngwa?

Adelmidrol bụ ihe nrụpụta semisynthetic nke azelaic acid na analog nke ogige mgbochi mkpali palmitoylethanolamide (PEA), aliamide na onye otu ezinụlọ nke fatty acid amide na-egosi ụmụ irighiri ihe nwere cannabimimetic Njirimara. E gosipụtara mmetụta mgbochi mkpali na antinociceptive nke aliamides PEA na adelmidrol n'ọtụtụ ọmụmụ ụlọ ọgwụ tupu oge eruo, ma na vitro na na vivo. A na-eche na omume ha bụ n'ihi, opekata mpe n'otu akụkụ, n'ihi ikike ha nwere ime ka mgbaka mast cell rụọ ọrụ na mwepụta onye ogbugbo mast cell na ọnọdụ pathophysiological na pathological.

Adelmidrol powder n'ihi na ire(Ebe ịzụta Adelmidrol ntụ ntụ na nnukwu)

Ụlọ ọrụ anyị na-enwe mmekọrịta ogologo oge na ndị ahịa anyị n'ihi na anyị na-elekwasị anya na ndị ahịa ọrụ na inye nnukwu ngwaahịa. Ọ bụrụ na i nwere mmasị na anyị ngwaahịa, anyị na-agbanwe na customization nke iwu ona gị kpọmkwem mkpa na anyị ngwa ngwa ụzọ oge na iwu emesi ị ga-enwe oké akatabi okop ngwaahịa anyị na-oge. Anyị na-elekwasịkwa anya na ọrụ ndị bara uru. Anyị dị maka ajụjụ ọrụ na ozi iji kwado azụmahịa gị.

Anyị bụ ndị ọkachamara Adelmidrol ntụ ntụ soplaya ruo ọtụtụ afọ, anyị na-enye ngwaahịa na ọnụahịa asọmpi, na ngwaahịa anyị bụ nke kachasị mma ma na-enweta nyocha siri ike, nke onwe ya iji hụ na ọ dị mma maka oriri na gburugburu ụwa.

References

1. Cerrato, Santiago; Brazil, Pilar; della Valle, Maria Federica; Miolo, Alda; Puigdemont, Anna (2012). "Mmetụta mgbochi nke Adelmidrol Topical na antigen na-ebute akpụkpọ anụ wheal na mast cell na ụdị canine nke nrịanrịa dermatitis." BMC nchọpụta ọrịa anụmanụ. 8 (1): 230. doi:10.1186/1746-6148-8-230. PMC 3540011. PMID 23181761.
2. Cordaro, M; Impellizzeri, D; Gugliando, E; Siracusa, R; Crọpi, R; Esposito, E; Cuzzocrea, S (2016). "Adelmidrol, Palmitoylethanolamide Analogue, dị ka ọgwụgwọ ọgwụ ọhụrụ maka njikwa ọrịa afọ na-efe efe". Nkà mmụta ọgwụ molecular. 90 (5): 549–561 . doi:10.1124/mol.116.105668. PMID 27625036.
3. Abramo, F; Salluzi, D; Leotta, R; Auxilia, S; Nọlị, C; Miolo, A; Mantis, P; Lloyd, D. H (2008). "Mkpụrụ ndụ mast cell morphometry na densitometry na ọnya anụ ahụ nnwale ejiri gel nwere adelmidrol: Ọmụmụ ihe na-achịkwa placebo." Ọnya : Ngwakọta nyocha na omume ụlọ ọgwụ. 20 (6): 149–57 . PMID 25942520.

Nweta nnukwu ọnụ ahịa