Nicotinamide Riboside Chloride (NR) (23111-00-4) Onye nrụpụta - Cofttek

Nicotinamide Riboside Chloride (NR) (23111-00-4) Ọgwụ

April 7, 2020

Nicotinamide riboside, nke a makwaara dị ka NR na SRT647, bụ ụdị pyridine-nucleoside nke vitamin B3 nke na-arụ ọrụ dị ka ihe ga - eme ka nicotinamide adenine dinucleotide ma ọ bụ NAD +. NR gbochiri nbibi nke akwara dorsal root ganglion neurons ex vivo ma chekwaa oke mkpọtụ ntị na-akpata na ụmụ oke.

 


ọnọdụ: Na Production Production
Otu: 1kg / akpa, 25kg / Drum

 

Nicotinamide Riboside Chloride (NR) (23111-00-4) vidiyo

 

Nicotinamide Riboside Chloride (NR) Ihe Smmezi

aha: Nicotinamide Riboside Chloride (NR) Ihe
CAS: 23111-00-4
ọcha 98%
Usoro Molecular: C11H15ClN2O5
Molekụla arọ: 290.7 g / mol
Melt Point: 115-125 ℃
Aha aha: 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
Synonyms: Nicotinamide riboside; SRT647; SRT-647; SRT 647; Nicotinamide Riboside Triflate, ngwakọta α / β
KeyInChI: YABIFCKURFRPPO-FSDYPCQHSA-N
Ọkara ndụ: 2.7 awa
Solubility: Nsogbu na DMSO, Methanol, Mmiri
Ọnọdụ Nchekwa: 0 - 4 C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 C maka ogologo oge (ọnwa)
ngwa: A na-ekwu na Nicotinamide riboside bụ ụdị ọhụụ nke pyridine-nucleoside nke vitamin B nke na-arụ ọrụ dị ka ihe ga - enyere aka nicotinamide adenine dinucleotide ma ọ bụ NAD +.
anya: Gbanyụọ White ka icha mmirimmiri edo edo

 

Gini bu Nicotinamide Riboside Chloride (NR) CAS 23111-00-4?

Nicotinamide riboside, nke a makwaara dị ka NR na SRT647, bụ ụdị pyridine-nucleoside nke vitamin B3 nke na-arụ ọrụ dị ka ihe ga - eme ka nicotinamide adenine dinucleotide ma ọ bụ NAD +. NR gbochiri nbibi nke akwara dorsal root ganglion neurons ex vivo ma chekwaa oke mkpọtụ ịnụ ụda na ụmụ oke. Nicotinamide riboside na - egbochi akwara, neural na melanocyte stem cell senescence. Achọpụtala usoro ịmụgharị akwara dị n’ime ụmụ oke ka ọgịrịga dị nicotinamide gwọchara ya, na-eduga na ịkọ nkọ na ọ nwere ike ime ka akụkụ ahụ ndị dị ka imeju, akụrụ na obi pụta. Nicotinamide riboside na-ebelata glucose ọbara na imeju abụba na-arịa ụdị ọrịa mamịrị na ụdị ụdị ọrịa mamịrị 2 na-egbochi mmepe nke neuropathy ọrịa mamịrị. Mara: Nicotinamide Riboside chloride bụ ngwakọta α / β.

 

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 uru

Nicotinamide nucleosides bụ ihe ndị na-ebute ụzọ nke nicotinamide adenine dinucleotide (NAD) ma na-anọchite anya isi iyi nke vitamin B3. Ọmụmụ ihe ọmụmụ emere n’oge na-adịbeghị anya gosipụtara na ịba ụba nicotinamide nucleosides n’onwe ya na nri nwere ike inye uru ahụike ọhụụ. Iji maa atụ, a rụpụtara nicotinamide nucleosides n’ịbawanye n’ọkpụkpụ NAD na iwebata insulin yana yana ịkwalite ọrụ sirtuin. Ike ya ịbawanye mmepụta NAD na-egosi na nicotinamide nucleosides nwekwara ike melite ahụike mitochondrial, na-akpali ọrụ mitochondrial, ma na-ebute mmepụta nke mitochondria ọhụrụ. Ọmụmụ ihe ndị ọzọ na-eji nicotinamide nucleosides na usoro ọrịa Alzheimer egosila na molekul ahụ dị na ụbụrụ ma nwee ike inye neuroprotection site na ịkwalite ụbụrụ NAD ụbụrụ.

Nicotinamide Riboside Chloride nwekwara ike Belata ibu: Nnyocha egosila na site na ịbawanye ike metabolism, ị nwere ike belata nri abụba dị elu na-ebute uru bara ụba. Iji nyochaa usoro nicotinamide ribose nke NR na-akwalite ọnwụ, ndị na-eme nchọpụta tụrụ imeju mitochondrial imeju metụtara nri caloric, ọrụ, calorie, eriri gburugburu, izu ike metabolic izu ike, nhazi ahụ, nnabata glucose, insulin sensitivity na biochemical na metabolomics dị iche iche. kwa. Ihe omuma ndia na uzo ohuru ohuru site na malabsorption, iwepu ihe omuma nke ndu maka nlekota. Ndị nnyocha ahụ kwuru na ụmụ oke nri nicotinamide na-enyekwu ihe ndị na-akpata nicotinamide yikarịrị ka ha ga-atụfu ibu karịa ụmụ oke ndị na-agbakwunye nicotinamide

 

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 Usoro nke ime ihe?

Nicotinamide Riboside Chloride (NR) nucleosides bụ precursors nke nicotinamide adenine dinucleotide (NAD) ma na-anọchite isi iyi nke vitamin B3. Nnyocha e mere na nso nso a egosiwo na ịba ụba nicotinamide nucleosides nke dị na nri nwere ike inye uru ahụike ọhụrụ. Dịka ọmụmaatụ, nicotinamide nucleosides abanyela na anụ ahụ NAD na-arịwanye elu ma na-ebute mmetụta insulin yana ịkwalite ọrụ sirtuin. Ike ya ịbawanye mmepụta NAD na-egosi na nicotinamide nucleosides nwekwara ike imeziwanye ahụike mitochondrial, kpalie ọrụ mitochondrial, ma mee ka mmepụta nke mitochondria ọhụrụ. Nyocha ndị ọzọ na-eji nicotinamide nucleosides na ụdị ọrịa Alzheimer egosiwo na molekul ahụ dị na ụbụrụ ma nwee ike ịnye neuroprotection site na ụbụrụ NAD na-akpali akpali ..

 

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 ngwa

Ọmụmụ preclinical egosila na mgbakwunye nke nicotinamide ribose enweghị ike iwelie ọkwa NAD + ka ọ dị mma, kamakwa ịbawanye uru nke NAD + n'ime mmadụ, nke na-agaghị ekwe omume na vitamin B3.Studies gosipụtara na ozugbo nicotinamide ribose pụtara na sel, ahụ na-agbanwe ya ngwa ngwa ka ọ bụrụ NAD +. NAD ndị a + na-akpali usoro nke ịmalite njikọ intracellular nke mmepụta ike site na mitochondria

Nicotinamide Riboside Chloride nwere ike ịkwalite ọrụ mitochondrial, nke egosiri iji mee ka ngosipụta nke ihe nchebe mitochondrial electron transport chain, mee ka ikike mitochondrial membrane dịkwuo elu, ma mụbaa ọnụego ume iku ume na ọkwa ATP intracellular. Enwere ike ijikọ nke a na usoro mitochondrial dị elu. Ọrụ Mitochondrial na-agbadata ka anyị na-akawanye nká, nke a bụ ihe ịrịba ama nke ịka nká nke mkpụrụ ndụ na -akpata ahụ anyị na-ahụ. NR nwere ike ịkwalite ọrụ nke mitochondria ma gbochie afọ ime nke sel sel.

 

Nicotinamide Riboside Chloride (NR) Ihe powder n'ihi na ire(Ebe ị ga-azụta Nicotinamide Riboside Chloride (NR) ntụ ọka na nnukwu)

Companylọ ọrụ anyị na ndị ahịa anyị na-enwe mmekọrịta ogologo oge n'ihi na anyị na-elekwasị anya n'ọrụ ndị ahịa ma na-enye nnukwu ngwaahịa. Ọ bụrụ na ị nwere mmasị na ngwaahịa anyị, anyị na-agbanwe agbanwe na nhazi nke iwu iji kwekọọ na mkpa gị kpọmkwem na oge ngwụsị nke oge anyị na ntinye iwu nke nkwa ị ga-enwe nnukwu uto nke ngwaahịa anyị n'oge. Anyị na-elekwasịkwa anya n'ọrụ bara uru. Anyị dị maka ajụjụ ọrụ na ozi iji kwado azụmahịa gị.

 

Anyị bụ ọkachamara na akpọrọ Nicotinamide Riboside Chloride (NR) na-eweta ntụ ntụ ruo ọtụtụ afọ, anyị na-enye ngwaahịa na ọnụahịa asọmpi, ngwaahịa anyị dịkwa mma kachasị elu ma na-anwale nnwale siri ike iji hụ na ọ dị mma maka oriri gburugburu ụwa.

 

References

  • Chi Y, Sauve AA. Nicotinamide riboside, ụdị nri na-edozi ahụ n'ime nri, bụ vitamin B3 nke nwere mmetụta metabolism ike na neuroprotection. Nlekọta Curr Opin Clin Nutr Metab. 2013 Nọvemba; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Nyocha. PubMed PMID: 24071780.
  • Bogan KL, Brenner C. Nicotinic acid, nicotinamide, na riboside nicotinamide: ntule nke mkpụrụ ndụ NAD + na-ebute vitamin na nri mmadụ. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Nyocha. PubIDed PMID: 18429699.
  • Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation dị ka sel-intrinsic, onye na-anya usoro nchekwa nchekwa abụba: kemịkal na metabolic nke mgbanwe acetyl-lysine. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Nyocha. PubIDed PMID: 24050258; PubMed Central PMCID: PMC4113336.
  • Ihe niile I Kwesịrị Aboutmara Banyere Nicotinamide Riboside Chloride