Nicotinamide Riboside Chloride (NR) Ihe Smmezi

aha:	Nicotinamide Riboside Chloride (NR) Ihe
CAS:	23111-00-4
ọcha	98%
Usoro Molecular:	C11H15ClN2O5
Molekụla arọ:	290.7 g / mol
Melt Point:	115-125 ℃
Aha aha:	3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
Synonyms:	Nicotinamide riboside; SRT647; SRT-647; SRT 647; Nicotinamide Riboside Triflate, ngwakọta α/β
KeyInChI:	YAABIFCKURFRPPO-FSDYPCQHSA-N
Ọkara ndụ:	2.7 awa
Solubility:	Nsogbu na DMSO, Methanol, Mmiri
Ọnọdụ Nchekwa:	0 - 4 C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 C maka ogologo oge (ọnwa)
ngwa:	A na-ekwu na Nicotinamide riboside bụ ụdị ọhụrụ pyridine-nucleoside nke vitamin B₃ nke na-arụ ọrụ dị ka ihe mmalite nicotinamide adenine dinucleotide ma ọ bụ NAD +.
anya:	Gbanyụọ White ka icha mmirimmiri edo edo

Nicotinamide Riboside chloride

Ahụ mmadụ bụ ihe dị mgbagwoju anya nke nwere mkpụrụ ndụ, anụ ahụ, na usoro akụkụ ahụ. A na-ahazi ọrụ nke ọma nke mkpụrụ ndụ na anụ ahụ dị n'ime ahụ site na kemịkalụ dị iche iche, enzymes, na nri. Ụfọdụ n'ime ahụ ndị a nwere ike ime onwe ha, na ụfọdụ ga-eri. N'ihi ya, nri ndị a dị n'ụdị nri na mgbakwunye. Otu n'ime ihe ndị a nwere ike inye aka gwọọ na ịhazi ahụ bụ nicotinamide riboside chloride (NR). Ọ na-enyere aka ịbawanye ego nke nicotinamide adenine dinucleotide (NAD +) n'ime ahụ.

Kedu ihe Nicotinamide Riboside Chloride na -eme?

Nicotinamide Riboside Chloride, nke a na-akpọkwa NR, bụ pyridine nucleoside nke vitamin B3. Ọ na-arụ ọrụ dị ka onye na-ebu ụzọ maka nicotinamide adenine dinucleotide (NAD+). Ọ dị ka ntụ ntụ na-acha odo odo na-acha ọcha ma na-acha odo odo. Ọ bụ otu n'ime ihe mmalite NAD + kacha mụọ nke ọma n'ihi na o nwere ọtụtụ uru ahụ ike.

Ejikọtara NAD+ ka ọ bụrụ otu n'ime ihe ndị bụ isi na -arụ ọrụ na usoro homeostasis dị iche iche na ahụ. Ọ nwere ike inye aka idobe ahụ ike, na -abawanye ndụ ndụ sel, na -enyere aka ịrụ ọrụ metabolic dị iche iche yana nyere aka n'ịgwọ ọrịa pathophysiologies dị iche iche na ahụ.

NR ntụ ntụ egosila arụmọrụ dị ka ọgwụgwọ na -arị elu n'ọrịa dị iche iche. N'ọtụtụ ọgwụ, NR nwere ike ịgwọ ọnọdụ dịka ọrịa obi, ọrịa neurodegenerative, ọrịa mọzụlụ, na nsogbu metabolic. E gosipụtakwala NR na -egbu oge ịka nká nke mkpụrụ ndụ ma gbatịkwuo ndụ ha. A na -ahụ ya na ngwaahịa nri dị ka azụ, ọkụkọ, akwa, mmiri ara, na ọka.

Kedu ihe Nicotinamide Riboside Chloride na -eme?

Iji ghọta ihe nicotinamide riboside chloride na -eme, anyị ga -ebu ụzọ ghọta nicotinamide adenine dinucleotide ma ọ bụ NAD+.

NAD+ bụ coenzyme dị mkpa na ahụ mmadụ. Ọ na -arụ ọrụ na -eduzi ụzọ metabolic dị iche iche. Ọnụnọ ya n'ime ahụ dị mkpa maka ịgwọ ọtụtụ ụdị ọrịa. Ọ na -enye aka imepụta ume maka ụbụrụ, sel na -alụso ọrịa ọgụ, na mọzụlụ.

Ọnụ ego NAD+ nke enwere ike nweta site na isi nri dị ntakịrị. Nke a ezughị maka ọtụtụ selụ nke ahụ iji. Yabụ imepụta ya, ahụ na -aga ụzọ dị iche iche. Enwere ụzọ ụzọ atọ nke enwere ike ijikọ NAD+. Ụzọ De novo njikọ, ụzọ Preiss Handler, na ụzọ nzọpụta.

Ụzọ nzọpụta bụ usoro a na-ejikarị eme NAD + n'ime ahụ. N'ụzọ a, NAD + na-enweta mmeghachi omume redox. Ọ na-agụnye ịbelata site na ihe nhata abụọ-electron, nke ga-aghọzi ụdị a na-akpọ nicotinamide adenine dinucleotide (NADH). Ebe ọ bụ na nri mgbakwunye ezughị ezu maka mkpa anụ ahụ maka NAD +, ụzọ mgbapụta na-eji ma na-eji NAD dị adị na ụdị ya dị iche iche.

Otu n'ime isi ihe NAD+ na -eme bụ ịgbalite sirtuins, otu enzyme 7, Sirt1 ruo Sirt7. Enzymes ndị a nwere ọrụ nke ịchịkwa ịka nká na ogologo ndụ nke sel. Sirtuins na -arụ ọrụ n'ọtụtụ usoro metabolic, dị ka mwepụta insulin, mkpokọta nke lipids, na nzaghachi nrụgide. Ọ nwedịrị ike ịhazi ogologo ndụ. A na -arụ ọrụ Sirtuins mgbe ọkwa NAD+ bilitere.

NAD+ bụkwa mkpụrụ maka otu protein ndị akpọrọ poly ADP-ribose polymerase (PARP). Ọ bụ ya kpatara nrụzi na nkwụsi ike nke DNA na mkpụrụ ndụ ihe nketa yana ọ nwekwara ike bụrụ ọrụ maka ogologo ndụ.

Ọkwa NAD+ na -adalata n'ihi afọ na ọrịa. Ụfọdụ ihe kpatara mbelata ya bụ nfụkasị na -adịghị ala ala, ịgbalite usoro ahụ ji alụso ọrịa ọgụ, yana ibelata ọrụ nicotinamide phosphoribosyltransferase (NAMPT), na -eduga n'ịbelata mmepụta ya. Ka ahụ mmadụ na -eto, ogo mmebi DNA na -abawanye site na obere ohere iji rụzie, na -akpata ịka nká na ọrịa kansa.

Enwere ụzọ ole na ole iji bulie ọkwa NAD+ n'ime ahụ. Ha na -eri obere nri ma na -achịkwa ọnụ ọgụgụ kalori, ibu ọnụ, na mmega ahụ. Ihe omume ndị a nwekwara ike inye aka mee ka ahụ dị mma ma na -arụkwa ọrụ.

Usoro ndị ọzọ na-abawanye NAD + gụnyere iri tryptophan na niacin na ị na-ewere NAD + boosters dị ka nicotinamide riboside chloride na nicotinamide mononucleotide.

Nicotinamide riboside chloride bụ ihe na -ebute ụzọ nke nwere ike ịbawanye ọkwa cellular nke NAD+. Ọ bụkwa isi iyi nke vitamin B3. Ọ bụ ngwaahịa na -arụ ọrụ n'ụzọ nzọpụta nke mmepụta NAD+. Ọ na -atụgharị n'ime nicotinamide mononucleotide (NMN) site n'enyemaka nke enzyme NR kinase Nrk1. Ọ tụgharịrị gaa na NAD+.

Mgbe ịnyechara NR, ọkwa NAD+ na -abawanye n'ahụ, nke a na -ekesa ya n'akụkụ dị iche iche. Ọ nweghị ike ịgafe ihe mgbochi ụbụrụ ọbara, mana ọ na-agbanwe ka ọ bụrụ nicotinamide nke a na-ebuga ya na ụbụrụ na akwara ndị ọzọ ebe ọ mejupụtara NAD+.

Imirikiti ozi gbasara ịdịmma nke Nicotinamide Riboside chloride sitere na nyocha anụmanụ. Nnyocha nyocha nke mmadụ ka nwere oke, ọ dịkwa nnukwu mkpa.

Uru Nicotinamide Riboside Chloride

Enwere ọtụtụ uru iji Nicotinamide Riboside chloride. Ha bụ:

Mmetụta na Ọrịa Neuromuscular

Nicotinamide riboside chloride ike ịbawanye NAD + nwere ike imeziwanye ọrụ nke mitochondria. Nke a nwere ike inye aka n'ịgwọ ọrịa mitochondrial myopathies [1]. NR ntụ ntụ egosikwara na ọ dị irè n'ịkwalite ọrụ nke dystrophy muscular.

Mmetụta na ọrịa obi

Nsogbu ọ bụla na metabolism NAD+ nwere ike ibute nsogbu na obi na arịa ọbara. Ọ nwere ike bute ọnọdụ dịka nkụda obi, oke ibu, infarction myocardial, wdg NR mmeju nwere ike weta oke NAD + na nicotinamide adenine dinucleotide + hydrogen (NADH) ka ọ dị mma wee kwụsị nrụzigharị adịghị mma nke anụ ahụ [2]. Ọ nwekwara ike weghachite mmetụta nke nkụda obi.

Mmetụta na ọrịa neurodegenerative

Ọrịa neurodegenerative na -emekarị na ịka nká. Ejikọtara ha na nrụgide oxidative nke nwere ike ibute DNA. Ọtụtụ mgbe, a ga -enwe omume na -adịghị mma nke mitochondria, na -eso ihe ụfọdụ mgbe mkpụrụ ndụ agaghị enwe ike ịrụ ọrụ nke ọma. NAD+ na -agbada na ego ka ahụ na -eto, na -eduga n'ịrụ ọrụ mitochondria. Nke a nwere ike ibute ọrịa neurodegenerative dị iche iche. Ọ nwekwara ike ịbawanye ohere nke ọrịa Alzheimer.

Nicotinamide Riboside chloride na-abawanye ọnụọgụ NAD + n'ime ahụ, na-ebelata nrụgide oxidative, ma nwee ike ịrụkwa DNA mebiri emebi. Ọ na-enyekwara aka n'ịgwọ ọrịa Alzheimer na ụmụ oke [3]. Ọ nwekwara ike ibelata mbufụt na ụbụrụ, na-enyere aka melite cognition na ebe nchekwa [4]. Ọ nwere ike ime nke a site n'ibelata protein amyloid-β precursor na igbochi amyloidogenesis.

NR ntụ ntụ nwekwara ike ịkwụsị mmebi nke axons n'ụdị adịghị ala ala nke ọrịa neurodegenerative site n'ịgbanwe metabolism nke NR na axon [5]. Mmebi nke neurons na -agagharị agagharị nke na -etinye mkpụrụ ndụ ntutu cochlear nwere ike ime mgbe ekpughere ya na oke mkpọtụ. NR egosila na ọ dị irè n'igbochi mkpọtụ ụda butere mkpọtụ. Ọ na-eme nke a site na ime ihe sirtuin ma ọ bụ SIRT3 dabere na-ebelata mmebi neurite [6].

Mmetụta na ndị ọrịa mamịrị

Nicotinamide ribonucleoside chloride egosila na ọ dị irè n'ibelata ihe mgbaàmà nke nsogbu metabolic dị ka ụdị ọrịa shuga nke abụọ [7]. E gosiputara ya iji meziwanye nnabata glucose, belata ibu ma gwọọ mmebi imeju na ụmụ oke. Yabụ na ọ nwere ike ịdị irè n'ịgwọ mmadụ.

Mmetụta na ahụike imeju

Achọpụtala ọnọdụ imeju dị ka ọrịa imeju abụba na-adịghị egbu egbu na-akpata ụkọ NAD +. Ya mere, ịgbakwunye ntụ ntụ NR nwere ike inye aka maka mgbake ka mma na ọnọdụ ndị a [8].

Mmetụta na ịka nká

A chọpụtakwara na NAD+ na -ebelata ịka nká nke mkpụrụ ndụ ma na -eme ka ha dịghachi ndụ. Achọpụtala ya ka ọ na -akwalite ọrụ sel sel nke na -enyekwa aka ibelata ịka nka [9].

Uru Nicotinamide Riboside Chloride karịrị ndị NAD+ ndị bu ụzọ

NR nwere bioavailability ka mma yana ọ dị nchebe iji ya ma e jiri ya tụnyere ndị bu ụzọ. E gosiputara na ọ na -abawanye ọkwa NAD+ karịa na oriri ọnụ na ụmụ oke yana na -enyekwu NAD+ na mọzụlụ ma e jiri ya tụnyere ihe ndị ọzọ. Ọ nwekwara ike ịchịkwa ọkwa lipid ọbara nke ọma ma bulie ọkwa NAD+ n'ime obi [10].

Mmetụta dị n'akụkụ Nicotinamide Riboside Chloride

Nri ọnụ nke nicotinamide riboside chloride na obere doses adịghị mma. O nwere ike ịgụnye ụfọdụ mmetụta dị ka

ọgbụgbọ
Ịbanye ọbara
Edema
Itching
ike ọgwụgwụ
isi ọwụwa
afọ ọsịsa
Upset afo
Nri
vomiting

Etu esi azụta Nicotinamide Riboside Chloride?

Ọ bụrụ n'ịchọrọ ịzụta ntụ ntụ NR, ọ kacha mma ịkpọtụrụ ụlọ ọrụ mmepụta ihe Nicotinamide Riboside Chloride. Ọ na -agba mbọ hụ na ejiri ihe kachasị mma maka mmepụta, n'okpuru anya ndị ọkachamara na ngalaba metụtara ya. A na -eme ngwaahịa ndị a site na ntuziaka nchekwa siri ike nke na -ahụ na ngwaahịa a dị oke mma, yana nnukwu ike, yana kwakọbara nke ọma. Dị ka mkpa onye ọrụ si dị, enwere ike ịhazi iwu ahụ ka ọ dabaa n'ụdị ụtọ ha.

Ozugbo emere ngwaahịa a, ekwesịrị idobe ya na oyi oyi nke 0 ruo 4C maka obere oge yana -20C maka ogologo oge. Ọ bụ iji gbochie ya imebi ma ọ bụ meghachi omume na kemịkal ndị ọzọ na gburugburu.

References

Chi Y, Sauve AA. Nicotinamide riboside, ụdị nri na-edozi ahụ n'ime nri, bụ vitamin B3 nke nwere mmetụta metabolism ike na neuroprotection. Nlekọta Curr Opin Clin Nutr Metab. 2013 Nọvemba; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Nyocha. PubMed PMID: 24071780.
Bogan KL, Brenner C. Nicotinic acid, nicotinamide, na riboside nicotinamide: ntule nke mkpụrụ ndụ NAD + na-ebute vitamin na nri mmadụ. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Nyocha. PubIDed PMID: 18429699.
Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation dị ka sel-intrinsic, onye na-anya usoro nchekwa nchekwa abụba: kemịkal na metabolic nke mgbanwe acetyl-lysine. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Nyocha. PubIDed PMID: 24050258; PubMed Central PMCID: PMC4113336.
Ihe niile I Kwesịrị Aboutmara Banyere Nicotinamide Riboside Chloride