GABA ntụ ntụ (56-12-2)

Smmezi

Gamma-aminobutyric acid (GABA) (56-12-2) NMR ụdịdị dị iche iche

Ọ bụrụ na ịchọrọ COA, MSDS, HNMR maka ụdị ngwaahịa ọ bụla na ozi ndị ọzọ, biko kpọtụrụ anyị njikwa ahia.

Gini bu Gamma-aminobutyric acid?

Gamma aminobutyric acid (GABA) bụ amino acid dị n’arụ nke na - arụ ọrụ dị ka ụbụrụ akwara na ụbụrụ gị. Neurotransmitters na-arụ ọrụ dị ka ndị ozi kemịkal. A na-ewere GABA dị ka ihe na-egbochi ụbụrụ n'ihi na ọ na-egbochi, ma ọ bụ na-egbochi, ụfọdụ ụbụrụ na-egosi ma na-ebelata ọrụ na usoro ụjọ gị.

Gamma-aminobutyric acid (GABA) ntụ ntụ bụ neurotransmitter endogenous nke na-achịkwa excitability neuronal, ụda akwara, uto cell cell, mmepe ụbụrụ, na ọnọdụ. N'oge mmepe, GABA na-arụ ọrụ dị ka neurotransmitter na-akpali akpali mana ọ na-emesị gbanwee gaa na ọrụ mgbochi. GABA na-egosiputa anxiolytic, anticonvulsant, na mmemme mnestic, na-ebute ntụrụndụ na mbelata nchekasị na ntọala ụlọ ọgwụ. Ọrụ ya bụ isi bụ ibelata mkpali neuronal n'ime usoro ụjọ ahụ niile. A na-ere GABA ka a emeju nri.

GABA (56-12-2) uru

GABA maka ihi ụra

“GABA na-eme ka ahụ́ na uche nwee ike izu ike ma hie ezigbo ụra n’abalị ahụ dum,” ka Michael J. Breus, Ph.D., bụ́ ọkà n’akparamàgwà mmadụ na ọkachamara n’ihe banyere ụra, kwuru. A na-egosikwa ndị GABA-A na-anabata ihe na thalamus, mpaghara ụbụrụ nke metụtara usoro ihi ụra, na n'otu nnyocha, ndị ọrịa na-ehighị ụra nke ọma nwere ọnọdụ GABA fọrọ nke nta ka ọ bụrụ 30% dị ala karịa ndị na-enweghị nsogbu ihi ụra.

N'ime nnyocha e mere n'oge na-adịbeghị anya, ndị sonyere na-ewere 100 mg nke ụdị GABA (PharmaGABA) tupu ha lakpuo ụra ngwa ngwa ma nwee ezigbo ụra ụra karịa otu izu nke mgbakwunye.

“Mgbe ahụ gị na-emepụta [GABA], usoro ahụ gị ji arụ ọrụ na-ebelata, nke na-eme ka mmadụ nwee ahụ iru ala karị, na ọtụtụ mgbe ụra na-atụ. N'ezie, imirikiti ihe enyemaka ụra ugbu a na-akwado ọkwa GABA nkịtị n'ụbụrụ, "ka Breus na-ekwu.

Ọzọkwa, mgbakwunye na magnesium, nke bụ GABA agonist (ya bụ, ihe na-ejikọta na ndị na-anabata GABA ma na-eme ka ha dị ka GABA ga-eme, na-akọwa Ruhoy), egosila na ọ kwadoro àgwà ụra.

GABA maka nchekasị na echiche nchegbu

N'iburu ọrụ GABA n'ịmezi mmetụta nke glutamine, a na-eche na ọ na-enye aka ịnọgide na-enwe mmetụta nke nrụgide na nlele (nke a bụ ihe kpatara ọtụtụ ọgwụ ndị na-egbochi ụjọ na-eche ndị GABA-A). Ọtụtụ nnyocha na-egosi otú ọkwa GABA zuru oke nwere ike isi mee ka mmetụta dị jụụ.

N'otu obere ọmụmụ ihe, ndị na-eme nchọpụta nwere ndị sonyere na-eri ma ọ bụ mmiri gbapụrụ agbapụ, mmiri dịpụrụ adịpụ na L-theanine (ihe dị jụụ na akwụkwọ ndụ akwụkwọ ndụ tii), ma ọ bụ mmiri distilled nwere ụdị GABA (PharmaGABA). Nkeji iri isii ka nke ahụ gasịrị, ha ji ụbụrụ elektrọniklogram (EEG) tụọ ụbụrụ ụbụrụ ha ma chọpụta na GABA mụbara ụbụrụ ụbụrụ ndị sonyere (nke a na-eme na ọnọdụ izu ike) ma belata ụbụrụ ụbụrụ (nke a na-ahụkarị n'ọnọdụ nsogbu) ma e jiri ya tụnyere L mmiri ma ọ bụ mmiri.

Na nnwale ọzọ nke otu ndị na-eme nchọpụta mere, ndị sonyere na egwu nke elu natara ma ọ bụ placebo ma ọ bụ 200 mg GABA (n'ụdị PharmaGABA) tupu ha agafee akwa nkwusioru na-adịghị agafe na kanyon. A tụrụ ọkwa dị iche iche nke ọgwụ mgbochi immunoglobulin-A (sIgA) —nke ejikọtara ya na izu ike na ọkwa dị elu - n'ọtụtụ ọkwa. Otu placebo ahụ nwere nnukwu ndapụta na sIgA, ebe ọkwa ndị otu GABA kwụsiri ike na ọbụnadị uto ntakịrị site na njedebe, na-egosi na ha nọrọ jụụ.

GABA na uche

Nnyocha na-egosi na GABA nwere ike inwe mmetụta dị mma na ikike mmadụ nwere ịrụ ọrụ uche nke chọrọ itinye uche dị ukwuu ma belata ma ike mmụọ na ike ọgwụgwụ nke na-emebikarị uche a.

N'ime otu obere ọmụmụ ihe, enyere ndị sonyere (ọtụtụ n'ime ha ike ọgwụgwụ) na-enye ihe ọ containingụ beụ nke nwere 0, 25, ma ọ bụ 50 mg nke GABA wee rịọ ka ha mee nsogbu mgbakọ na mwepụ siri ike. Ndị nchọpụta chọpụtara na ndị nọ na otu GABA abụọ ahụ nwere nnukwu mmụba na ike ọgwụgwụ mmụọ na nke anụ ahụ, dị ka atụpụtara site na mbelata ụfọdụ ndị na-emepụta biomarkers gụnyere cortisol. -mkpezi ike.

GABA maka ọbara mgbali elu

Nnyocha nke mbido na-egosi na GABA nwere ike ịkwalite ọbara mgbali elu dị mma, opekata mpe dịka ọmụmụ ụlọ nyocha ole na ole. Echere na GABA nwere ike ime ihe site n'inyere arịa ọbara aka ka ọ bawanye nke ọma, si otú a na-akwalite ọbara mgbali elu.

Ịghọta otu GABA nwere ike isi dị irè maka ịkwado ọbara mgbali elu ga-achọ nyocha siri ike karị, mana otu nnyocha mbụ chọpụtara na kwa ụbọchị. Mgbakwunye na 80 mg nke GABA nwere mmetụta dị mma na ọbara mgbali na ndị okenye.

Gamma-aminobutyric acid ojiji?

Gamma-aminobutyric acid-nke a na-akpọkarị GABA-bụ amino acid na neurotransmitter, ụdị kemịkalụ maka ibuga ozi site n'otu cell gaa na nke ọzọ.

Emepụtara n'onwe ya na ahụ, GABA dịkwa n'ụdị mgbakwunye. Ndị na-emepụta na-ekwu na GABA ihe mgbakwunye nwere ike inye aka kwalite ọkwa GABA ụbụrụ na ọgwụgwọ nchekasị, nchekasị, ịda mbà n'obi, na nsogbu ihi ụra. N'ezie, ụfọdụ ndị na-emepụta ihe mgbakwunye na-akpọ GABA "ụdị Valium" - nke pụtara na ọ na-ebelata nchekasị ma na-eme ka ntụrụndụ na ụra dịkwuo mma.

Nnyocha na-egosi na GABA nwere ike ịrụ ọrụ dị mkpa n'ichebe ịda mbà n'obi na nchekasị. Dịka ọmụmaatụ, otu nnyocha e bipụtara na Journal of Biological Chemistry na 2010 na-egosi na ndị nwere isi ịda mbà n'obi O yikarịrị ka ọ ga-enwe ọkwa dị ala nke GABA.2 Na nchọpụta 2009 na ịba ụba GABA nwere ike ịba uru na ọgwụgwọ egwu egwu. Nsonaazụ ndị a kwekọrọ n'eziokwu ahụ bụ na GABA bụ isi ihe na-eme ka ahụ dị jụụ (inhibitory) neurotransmitter na ụbụrụ.

usoro ogwu

A na-eji GABA n'ọnụ iji belata nchekasị, imeziwanye ọnọdụ, ibelata mgbaàmà nke ọrịa premenstrual syndrome (PMS), na ịgwọ ọrịa mpe-hyperactivity disorder (ADHD). A na-ejikwa ya maka ịkwalite uto ahụ ike, abụba na-ere ọkụ, ime ka ọbara mgbali elu, na ibelata ihe mgbu.

N'ihi na enwere oke ozi gbasara mgbakwunye GABA, enweghị usoro ọgwụ akwadoro ma ọ bụrụ na ịhọrọ ịgbakwunye.

N'ime ule nyocha, ejirila ọtụtụ ọgwụ GABA. Dịka ọmụmaatụ, 100 milimita nke mmiri ara ehi fermented nwere 10-12 mg nke GABA kwa 100 mL ka ndị ọrịa nwere ọbara mgbali elu jiri mee nnyocha ebe ha na-a consumedụ ihe ọ drinkụ drinkụ kwa ụbọchị na nri ụtụtụ maka izu 12. N'ọmụmụ ihe ọzọ, a na-ewere ihe mgbakwunye chlorella nwere 20 mg nke GABA ugboro abụọ kwa ụbọchị maka izu 12.

Geba powder n'ihi na ire(Ebe ịzụta GABA ntụ ntụ na nnukwu)

Ụlọ ọrụ anyị na-enwe mmekọrịta ogologo oge na ndị ahịa anyị n'ihi na anyị na-elekwasị anya na ndị ahịa ọrụ na inye nnukwu ngwaahịa. Ọ bụrụ na ị nwere mmasị na anyị ngwaahịa, Anyị na-agbanwe na customization nke iwu dabara gị kpọmkwem mkpa na anyị ngwa ngwa ụzọ oge na iwu na-ekwe nkwa na ị ga-enwe oké akatabi okop anyị ngwaahịa na-oge. Anyị na-elekwasịkwa anya na ọrụ ndị bara uru. Anyị dị maka ajụjụ ọrụ na ozi iji kwado azụmahịa gị.

Anyị bụ ndị ọkachamara GABA ntụ ntụ soplaya ruo ọtụtụ afọ, anyị na-enye ngwaahịa na asọmpi ọnụahịa, na ngwaahịa anyị bụ nke kachasị mma ma na-enweta nyocha siri ike, nke onwe ya iji hụ na ọ dị mma maka oriri gburugburu ụwa.

References

[1] Haynes, William M., ed. (2016). Akwụkwọ CRC nke Chemistry na Physics (nke iri asaa na itoolu.). CRC Pịa. peeji nke 97-5. ISBN 88-978.

[2] WG Van der Kloot; J. Robbins (1959). "Mmetụta nke GABA na picrotoxin na njikọta nwere njikọta na nkenke nke uru crayfish". Ahụmahụ. 15: 36.

[3] Roth RJ, Cooper JR, Oge ntoju FE (2003). Usoro biochemical nke Neuropharmacology. Oxford [Oxfordshire]: Mahadum Oxford University. peeji nke. 106. ISBN 978-0-19-514008-8.

Nweta nnukwu ọnụ ahịa