Urolithin A ntụ ntụ

Urolithin A ntụ ntụ nkọwa

aha:	Urolithin A.
Chemical aha:	3,8-Dihydroxybenzo [c] chromen-6-one
CAS:	1143-70-0
Usoro Chemical:	C13H8O4
Ọbara arọ:	228.2
agba:	White na-acha ọcha ọcha ntụ ntụ
InChi Igodo:	RIUPLDUFZCXCHM-UHFFFAOYSA-N
Koodu SMILES:	O=C1C2=CC(O)=CC=C2C3=C(O1)C=C(O)C=C3
ọrụ:	Urolithin A, gut-microbial metabolite nke ellagic acid, nwere ọgwụ mgbochi, antiproliferative na akụrụngwa antioxidant. Urolithin A na - akpata Automoragy na apoptosis, na - egbochi mmepe okirikiri ma na - egbochi njikọ nke DNA.
ngwa:	Urolithin A bụ metabolite nke ellagitannin; Ndị na-ahụ maka ọgwụ
Solubility:	Nsogbu na DMSO (3 mg / mL).
Nchekwa Nche:	Akọrọ, ọchịchịrị na 0 - 4 C maka obere oge (ụbọchị ruo izu) ma ọ bụ -20 C maka ogologo oge (ọnwa ruo afọ).
Ọnọdụ Mbupu:	Ebubo n'okpuru okpomọkụ dị jụụ dị ka chemical na-adịghị ize ndụ. Ngwaahịa a zuru oke maka izu ole na ole n'oge njem nkịtị na oge ejiri mee ihe na Omenala.

 

Urolithin A. NMR ụdịdị dị iche iche

Ọ bụrụ na ịchọrọ COA, MSDS, HNMR maka ụdị ngwaahịa ọ bụla na ozi ndị ọzọ, biko kpọtụrụ anyị njikwa ahia.

 

Okwu Mmalite na Urolithins

Urolithins bụ metabolites nke abụọ nke ellagic acid sitere na ellagitannins. N'ime mmadụ ellagitannins na-agbanwe site na gut microflora n'ime ellagic acid nke na-agbanwe ọzọ n'ime urolithins A, urolithin B, urolithin C na urolithin D na nnukwu eriri afọ.

Urolithin A (UA) bụ ihe kachasị emetụta metabolite nke ellagitannins. Agbanyeghị, urolithin A amaghi na ọ na-eme n'ụzọ nkịtị na usoro nri ọ bụla.

Urolithin B (UB) bu ihe omuma di uku nke emeputara n'ime ime site na mgbanwe nke ellagitannins. Urolithin B bu nke ikpeazu mgbe emechara urolithin ndi ozo. Urolithin B dị na mmamịrị dị ka urolithin B glucuronide.

Urolithin A 8-Methyl Ether bụ ngwaahịa dị n'etiti n'etiti njikọ nke Urolithin A. Ọ bụ nnukwu metabolite nke abụọ nke ellagitannin ma nwee antioxidant na mgbochi mkpali Njirimara.

 

Usoro nke urolithin A na B

Rol Urolithin A na - ebute mitophagy

Mitophagy bụ otu ụdị arụrụ aka nke na - enyere aka wepu mitochondrial mebiri emebi maka ọrụ ha kachasị mma. Autophagy na-ezo aka na usoro izugbe nke ihe cytoplasmic mebiri emebi ma na-ejikwa ya emegharị mgbe mitophagy bụ mbibi na nrụgharị nke mitochondria.

N'oge ịka nká, mbelata nke autophagy bụ otu akụkụ na-eduga n'ịbelata ọrụ mitochondrial. Ọzọkwa, nrụgide oxidative nwekwara ike iduga obere autophagy. Urolithin A nwere ikike iwepu mitochondria mebiri emebi site na nhọrọ autophagy.

Njirimara antioxidant

Oxidative nrụgide na-eme mgbe enwere nghọtahie n'etiti radicals free na antioxidant dị na ahụ. Ihe ndi a n’emebi ihe n’emeghị nsogbu n’obi na-ejikọkarị ya na ọtụtụ ọrịa na-adịghị ala ala dịka ọrịa obi, ọrịa shuga na kansa.

Urolithins A na B na-egosipụta mmetụta antioxidant site na ikike ha iji belata radicals n'efu yana otu ọkwa oxygen intracellular reactive nke mkpụrụ ndụ (ROS) ma na-egbochi mkpụrụ ndụ peroxidation n'ụdị ụfọdụ.

Ọzọkwa, urolithins nwere ike igbochi ụfọdụ enzymes na-egbu egbu, gụnyere monoamine oxidase A na tyrosinase.

● Njirimara mgbochi

Mbufụt bụ usoro okike nke ahụ anyị na-alụ ọgụ megide ihe ọ bụla dara ada dị ka ọrịa, mmerụ ahụ, na ụmụ nje. Agbanyeghị, mbufụt na-adịghị ala ala nwere ike bụrụ ihe na-emerụ ahụ n'ihi na enwere nsogbu dị iche iche dịka ụkwara ume ọkụ, nsogbu obi, na kansa. Ọrịa na-adịghị ala ala nwere ike ime n'ihi nnukwu ọnya na-enweghị ọgwụgwọ, ọrịa ma ọ bụ ọbụna ihe na-akpata free na ahụ.

Urolithins A na B na-egosipụta ihe mgbochi mbufụt site na igbochi mmepụta nitric oxide. Ha na egbochi ọgwụ nitric oxide synthase (iNOS) inducible na mRNA nke na-ahụ maka mbufụt.

Effects Mmetụta nje na-alụso nje ọgụ

Besmụ nje gụnyere nje, fungi na nje na-ewere ọnọdụ na gburugburu ebe obibi yana n'ahụ mmadụ. Agbanyeghị, ụmụ nje ole na ole akpọrọ ọrịa nje nwere ike ibute ọrịa na-efe efe dị ka flu, ọrịa na ọrịa ịba.

Urolithin A na B nwere ike igosipụta mmeghachi omume antimicrobial site na igbochi sensor quorum. Orchọpụta Quorum bụ usoro nkwukọrịta nke nje na-enyere nje aka ịchọpụta na ịchịkwa usoro metụtara ọrịa dịka virulence na motility.

Hib Imechi glycation protein

Glycation na-ezo aka na njikọ nke shuga na-enweghị enzymatic. Ọ bụ akara biomarker na ọrịa shuga na nsogbu ndị ọzọ yana ịka nká.

Nnukwu protein protein bụ mmetụta nke abụọ nke hyperglycemia nwere ọrụ dị ukwuu na nsogbu metụtara ọrịa obi dịka ọrịa shuga na ọrịa Alzheimer.

Urolithin A na B nwere ihe ndị na-egbochi glycative nke nwere ọgwụ ndabere dabere na-akwụghị ụgwọ ọrụ antioxidant ha.

 

Urolithin A uru

(1) Nwere ike ịgbatị oge ndụ
Urolithin A na - akpata mitophagy site na iwezuga mitochondria mebiri emebi. Nke a na - asuresụrị nrụgharị nke mitochondria maka ịrụ ezigbo ọrụ. Mitochondria na-emebi ọtụtụ oge yana afọ yana n'ihi nrụgide. Ridchụpụ mitochondria mebiri emebi na-ekere òkè n'ịgbatịkwu afọ ndụ gị.

Na nyocha nke ikpuru, urolithin Ihe ndozi nke enyere na 50 µM site na akwa akwa ruo ọnwụ hụrụ ka ọ na-agbatị ndụ ha site na 45.4%.

N'ọmụmụ ihe ọzọ emere na 2019 n'iji fibroblasts senescent mmadụ, urolithin A mgbakwunye achọtara iji gosipụta ikike ịka nká. Ọ nwere ike ịbawanye okwu 1 nke collagen ma belata ngosipụta nke matriks metalloproteinase 1.

Obere ihe omumu mmadu gosiputara na UA nwere ike meziwanye oru mitochondrial na ahuike ndi mmadu n’egwuregwu mgbe ejiri onu me ya na 500-1000mg rue oge izu anọ.

(2) Nyere aka igbochi kansa prostate
Urolithins na njiri mara ha, ellagitannins, nwere ihe eji egbochi ọrịa kansa. Ha nwere ike igbochi mgbasa mkpụrụ ndụ kansa site na njide sel na ịbanye apoptosis. Apoptosis na-ezo aka na ọnwụ mkpụrụ ndụ nke ahụ mmadụ kpochapụrụ mkpụrụ ndụ cancer nwere na mkpụrụ ndụ ndị ọzọ nwere ọrịa.

Na nyocha nke ụmụ oke ji mkpụrụ ndụ kansa, ellagitannins metabolites (Urolithin A) chọpụtara na igbochi uto nke ọrịa kansa. Ọmụmụ ihe ahụ kọwakwara mkpara nke metabolites dị na gland prostate, muscle na anụ ahụ.

(3) Mmuta mmuta
Urolithin A nwere ike ichebe neurons site na ọnwụ ma nwee ike ịkpalite neurogenesis site na akara ngosi mgbochi mkpali.

N'ime ihe omumu banyere oke okike, a chọpụtara urolithin A ka oke ghara inwe nchekwube ma chekwaa neurons site na apoptosis. Nke a na-egosi na enwere ike iji UA na-agwọ ọrịa Alzheimer (AD).

(4) Imegide oke ibu
Nchọpụta e mere gosiri na ellagitannins na-enwe ike igbochi nnụchi egbugbere ọnụ yana ihe nrịbama ọrịa adipogenic dịka protein uto nke uto 2 yana protein na-ejikọ aka site na njide sel.

Achọpụtala Urolithin A ka ọ rụọ ọrụ iji mee ka insulin mara mma si otú a gbochie mmepe nke oke ibu.

Na nyocha nke ụmụ oke na oke ibu, urolithin A hụrụ mgbakwunye iji gbochie oke ibu oke ibu nri na oke mmezi nke ụmụ oke. Ọmụmụ ihe ahụ gosiri na ọgwụgwọ nke UA mụbara mmefu ike n'ihi ya ọ nwere oke ahụ.

 

Urolithin A na nri nri B

A maghị Urolithins n'ụzọ nkịtị na isi nri ọ bụla. Ha bụ ngwaahịa nke mgbanwe nke ellagic acid nke a na - enweta site na ellagitannins. A na-agbanwe Ellagitannins ka ọ bụrụ acids ellagic site na gita microbiota ma a na-agbanyekwu ọkụ acid n'ime metabolites (urolithins) na nnukwu eriri afọ.

Ellagitannins na-apụtakarị na isi mmalite nri dị ka pọmigranet, mkpụrụ osisi gụnyere mkpụrụ osisi strawberries, raspberries, Cloudberries na blakberị, mkpụrụ osisi muscadine, almọnd, guavas, tii, na mkpụrụ ndị dị ka walnuts na chestnuts yana mmanya na-eme agadi maka ihe atụ mmanya na-acha ọbara ọbara na whiskey si nnukwu osisi.

Ya mere anyi nwere ike ikwubi urolithin A nri na urolithin B nri bu nri ellagitannin bara ọgaranya. Okwesiri ighota na ellagitannin bioavailability nwere oke oke ebe ihe omuma ya nke abuo (urolithins) di ngwa ngwa.

Urolithins excretion na mmepụta dịgasị iche n'etiti ndị mmadụ ebe ọ bụ na ntụgharị si ellagitannins na-adabere na microbiota na eriri afọ. Enwere nje bacteria a kapịrị ọnụ na ntụgharị a ma dịgasị iche n'etiti ndị mmadụ ebe ụfọdụ nwere microbiota kwesịrị ekwesị, ma ọ bụ obere dị. Ebe nri dị iche iche dịkwa iche iche na ogo ellagitannins. N'ihi ya, uru bara uru nke ellagitannins dịgasị iche site n'otu onye gaa na nke ọzọ.

 

Urolithin A na B Mgbakwunye

Urolithin A mgbakwunye yana Urolithin B mgbakwunye na-achọta ngwa ngwa n'ahịa dị ka mgbakwunye mgbakwunye nri ellagitannin. Urolithin A Mmeju nwekwara ngwa ngwa. Karịsịa pọmigranet Mmeju e rere ọtụtụ ebe na-eji na-aga nke ọma. Ihe mgbakwunye ndị a na-esite na mkpụrụ osisi ma ọ bụ mkpụrụ wee mepụta ha mmiri ma ọ bụ ntụ ntụ.

N'ihi ọdịiche dị na nri ellagitannins na nri dị iche iche, ndị ahịa nke urolithin zụta ya na-echebara isi iyi nri. Otu ihe a na - emetụta mgbe ị na - agbakwunye urolithin B ntụ ntụ ma ọ bụ mmeju mmiri.

Ihe omumu omumu mmadu nke ejiri urolithin A uzuzu ma obu B emeghi ihe obula banyere nsogbu ndi ozo.

Reference

1. Garcia-Muñoz, Cristina; Vaillant, Fabrice (2014-12-02). "Ọdịdị Metabolic nke Ellagitannins: Mmetụta maka Ahụike, na Nchọpụta Nchọpụta maka Nri Na -arụ Ọrụ Ọhụrụ". Nyocha dị oke egwu na sayensị nri na nri.
2. Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (11 Nọvemba 2009). "Urolithins, eriri afọ microbial metabolites nke pọmigranet ellagitannins, na-egosipụta ọrụ antioxidant dị ike na nyocha nke sitere na sel". J Agric Food Chem.
3. Bodwell, Graham; Pottie, Ian; Nandaluru, Penchal (2011). "Nchọgharị elektrọnị na-achọgharị diels-njikọ nke ngụkọta nke okenye nke Urolithin M7".