α-ketoglutaric (328-50-7) (71686-01-6) - Emeputa factory

α-ketoglutaric

Cofftek nwere ikike imepụta ihe na ịnye Calcium 2-oxoglutarate na Alpha-Ketoglutaric Acid n'okpuru ọnọdụ nke cGMP.

Gịnị bụ Alfa-Ketoglutaric Acid (328-50-7)?

Alfa-ketoglutaric acid bu ihe ndi ozo n’ahu n’ime aru mmadu. Nakwa dị ka ihe oriri na-edozi ahụ, alpha-ketoglutaric acid na-arụ ọrụ dị mkpa na okirikiri Krebs (usoro mmeghachi omume kemịkalụ iji wepụta ike echekwara). A na-ekwu na ihe mgbakwunye Alpha-ketoglutaric acid na-enye ọtụtụ uru ahụ ike, gụnyere arụmọrụ egwuregwu na-arụ ọrụ nke ọma na mmelite metabolism.

Alpha-Ketoglutaric Acid (328-50-7) uru

Site na nke a, obere ọmụmụ ole na ole gosiri na enwere ike ị nweta mgbakwunye alpha-ketoglutaric acid. Nke a bụ ihe ụfọdụ nyocha ọhụụ kwuru:
Ọrịa Akụrụ Na-efe efe
Ejirila Alpha-ketoglutaric acid kemgbe mbubreyo 1990 iji nyere aka gbarie na ịmịkọrọ protein na ndị mmadụ na hemodialysis ndị chọrọ nri protein dị ala. Ihe akaebe na-egosi na ọ nwere ike igbu oge maka ịrịa ọrịa na ndị nwere ọrịa akụrụ na-adịghị ala ala (CKD). Dika nyocha nke 2017 n’ime akwukwo PLoS One, ndi nyocha choputara ma soro ndi mmadu 1,483 nwere CKD di elu nke jiri ihe mgbakwunye alpha-ketoglutaric akpọrọ Ketosteril. Ogologo oge nke ntinye ahụ bụ afọ 1.57. E jiri ya tụnyere otu ndị jikọtara ọnụ na-anaghị ewere mgbakwunye, ndị mere obere nwere ike ịchọ ịrịa ọrịa dị ogologo oge. Uru ndị a na-erubere nanị ndị na-ewere ihe karịrị mbadamba 5.5 kwa ụbọchị, na-egosi na mmetụta ndị ahụ na-adabere na dose. N’agbanyeghi nchoputa di nma, amataghi udiri alpha-ketoglutaric acid di ka ihe eji eme ihe ndi ozo. Ọ dị mkpa nyocha ọzọ.

Ahụike Ọrịa
A na-ekwenye na mgbakwunye Alpha-ketoglutaric acid bụ anticatabolic, nke pụtara na ọ na-ebelata ma ọ bụ na-egbochi ma ọ bụ catabolism (mmebi nke anụ ahụ). Site na nkọwa, usoro catabolic na-abụghị usoro anabolic (nke a na-ewu anụ ahụ). Nnyocha e mere na 2012 na Akwụkwọ akụkọ Italian nke Animal Science kọrọ na alpha-ketoglutaric acid gbochiri mmebi nke eriri afọ na oke nyocha na-enye nri na-enweghị protein maka ụbọchị 14. Kama inwe mmebi nke mkpịsị aka nke dịka eriri afọ nke eriri afọ-nsonaazụ a tụrụ anya ya - oke ndị ahụ nyere alpha-ketoglutaric acid enweghị mmebi a na-ahụ anya ma e jiri ya tụnyere oke na-adịghị. Ọzọkwa, oke ndị ahụ nyere ihe mgbakwunye ahụ nwere ike ịnọgide na-eto eto n'agbanyeghị enweghị protein. Ngwunye dị elu nyere ọbụna nsonaazụ kacha mma. Ihe nchoputa a gosiputara na-akwado nsogbu ogwu alpha-ketoglutaric acid. Na mgbakwunye na itinye ya n'ọrịa akụrụ na-adịghị ala ala, alpha-ketoglutaric acid nwekwara ike inyere ndị nwere ọrịa toxemia nsị na nsogbu malabsorption dị ka ọrịa celiac aka. Ọ dị mkpa nyocha ọzọ.

Ọrụ Egwuregwu
N'ụzọ dị iche, mmetụta nke anticatabolic nke alpha-ketoglutaric acid na-ada ka ọ na-ada ada mgbe ejiri ya maka ebumnuche nke uto ahụ na egwuregwu. Dabere na nyocha nke 2012 na Journal of the International Society of Sports Nutrition, alpha-ketoglutaric acid enweghị mmetụta pụtara ìhè na ike ike ma ọ bụ nwee ntachi obi na ụmụ nwoke 16 na-arụ ọrụ mgbatị ahụ. Maka ọmụmụ ihe a, e nyere ọkara nke ndị nwoke 3,000-milligrams (mg) nke alpha-ketoglutaric acid, ebe ọkara nke ọzọ nyere placebo minit 45 tupu ha eme egwuregwu pịa na mgbatị ụkwụ. N’izu na-eso ya, a gbanwere ihe mgbakwunye ahụ, ọkara nke ọ bụla na-enweta ọgwụ ọzọ. Egwuregwu na-adabere na mkpokọta ibu ibu (TLV) nke mmega ahụ emere na tandem yana tupu na mmega ahụ mgbatị obi. Ihe nchọpụta ndị a gosipụtara bụ na enweghị catabolic nzaghachi abụghị otu ihe dịka nzaghachi anabolic, karịsịa n'etiti ndị na-eme egwuregwu.

Alpha-Ketoglutaric Acid (328-50-7) jiri?

N'ime ịwa ahụ obi, a na-enyefe mkpụrụ ọgwụ alpha-ketoglutaric mgbe ụfọdụ (n'ime akwara) iji belata mmebi nke akwara obi n'ihi mbenata ọbara na-ebelata. Ime nke a nwekwara ike ime ka ọbara gbasaa na akụrụ na-esote ịwa ahụ. Ojiji ya dika mgbakwunye bu ihe pere mpe. Ndị ọkachamara ọzọ kwenyere na alpha-ketoglutaric acid nwere ike ịgwọ ma ọ bụ gbochie ọtụtụ ọnọdụ ahụike, gụnyere:
  • Cataracts
  • -Adịghị ala ala ọrịa akụrụ
  • Hepatomegaly (imeju abawanye)
  • Toxemia eriri afọ
  • Ntughari onu
  • osteoporosis
  • Ahụike
  • Yist na-efe efe
N'ihi ọrụ ya na ịhapụ ike echekwara, a na-erekarị alpha-ketoglutaric acid dị ka mgbakwunye arụmọrụ egwuregwu. Somefọdụ ndị na-akwado ya na-ekwusi ike na mgbakwunye antioxidant a na-agbakwunye nwere ike belata ịka nká. Dị ka ọ na-adịkarị na mgbakwunye na-ekwu na ha na-emeso ọtụtụ ọnọdụ ndị na-enweghị njikọ, ihe akaebe na-akwado nkwupụta ndị a adịghị ike. Fọdụ, dị ka ihe mgbakwunye nke "mgbochi ịka nká" (dabere n'ụzọ dị ukwuu na nyocha 2014 metụtara ikpuru nematode), ókè na-agaghị ekwe omume.

Alfa-Ketoglutaric Acid (328-50-7) usoro onunu ogwu

Ihe mgbakwunye Alpha-ketoglutaric acid dị na mbadamba, capsule, na ntụ ntụ nwere ike ịchọta ngwa ngwa n'ịntanetị ma ọ bụ n'ụlọ ahịa ndị ọkachamara na mgbakwunye nri. Enweghị ụkpụrụ nduzi ụwa maka iji ojiji alpha-ketoglutaric kwesịrị ekwesị. Ihe mgbakwunye na-erekarị na usoro onunu sitere na 300 milligrams (mg) na 1,000 mg were otu ugboro kwa ụbọchị ma ọ bụ na-enweghị nri. Ejirila ihe ruru 3,000 mg na ọmụmụ ihe na enweghị nsogbu ọ bụla.

Alpha-Ketoglutaric Acid (328-50-7) mmetụta ndị nwere ike

A na-ahụta Alpha-ketoglutaric acid dị ka ihe dị mma ma na-anabata ya nke ọma. Nnyocha na-enyocha mmetụta nke alpha-ketoglutaric acid kọrọ ọtụtụ ihe mgbaàmà na-adịghị mma mgbe afọ atọ gasịrị. Dị ka onyinye sitere na amino acid na-adịghị mkpa, alpha-ketoglutaric acid abụghị ihe ị ga - eri ngwa ngwa. Nbubata ọ bụla n'ime ahụ ga - ewepụ na mmamịrị ma ọ bụ gbasaa n'ime isi amino acid maka nzube ndị ọzọ. Site na nke a, echebeghị nchekwa nke alpha-ketoglutaric acid na ụmụ nwanyị dị ime, ndị nne na-enye nwa, na ụmụaka. Nke a gụnyere ụmụaka nwere obere nsogbu metabolism dị ka ụkọ alpha-ketoglutarate dehydrogenase (nke alpha-ketoglutaric acid dị elu).

Alpha-Ketoglutaric Acid ntụ ntụ maka ire ere (Ebee Ka Alphazụta Alpha-Ketoglutaric Acid na nnukwu)

Companylọ ọrụ anyị nwere mmekọrịta mmekọrịta ogologo oge na ndị ahịa anyị n'ihi na anyị na-elekwasị anya na ọrụ ndị ahịa na inye nnukwu ngwaahịa. Ọ bụrụ na i nwere mmasị na anyị ngwaahịa, anyị na-agbanwe na customization nke iwu ona gị kpọmkwem mkpa na anyị ngwa ngwa ụzọ oge na iwu emesi ị ga-enwe oké akatabi okop ngwaahịa anyị na-oge. Anyị na-elekwasịkwa anya na ọrụ ndị bara uru. Anyị dị maka ajụjụ ọrụ na ozi iji kwado azụmahịa gị. Anyị bụ ọkachamara ọkachamara-Alpha-Ketoglutaric Acid na-ebu ngwaahịa ọtụtụ afọ, anyị na-enye ngwaahịa na asọmpi ọnụahịa, ngwaahịa anyị kachasị mma ma na-anwale ule siri ike, nke onwe iji hụ na ọ dị mma maka oriri gburugburu ụwa.

Ntughari:

  1. Abrahams JP, Leslie AG, Lutter R, Walker JE. Nhazi na 2.8 Mkpebi nke F1-ATPase si na bovine obi mitochondria. Nature. 1994; 370: 621–628. ma ọ bụ: 10.1038 / 370621a0.
  2. Alpers DH. Glutamine: ihe data ahụ na-akwado ihe kpatara ntinye glutamine na ụmụ mmadụ? Ọrịa. 2006; 130: S106 – S116. ma ọ bụ: 10.1053 / j.gastro.2005.11.049.
  3. Ashkanazi J, Carpertier Y, Michelsen C. Akwara na plasma amino acid na-eso mmerụ ahụ. Ann Surg. 1980; 192: 78–85. ma ọ bụ: 10.1097 / 00000658-198007000-00014.