α-ketoglutaric (328-50-7) (71686-01-6) - Emeputa factory

Ọdịdị nke ketoglutaric

Cofftek nwere ikike imepụta ihe na ịnye Calcium 2-oxoglutarate na Alpha-Ketoglutaric Acid n'okpuru ọnọdụ nke cGMP.

Akwụkwọ ọkọlọtọ Cofttek

Zụrụ ntụ ntụ α-ketoglutaric

Budata akụrụngwa

Gịnị bụ Alfa-Ketoglutaric Acid (328-50-7)?

Alfa-ketoglutaric acid bu ihe ndi ozo n’ahu n’ime aru mmadu. Nakwa dị ka ihe oriri na-edozi ahụ, alpha-ketoglutaric acid na-arụ ọrụ dị mkpa na okirikiri Krebs (usoro mmeghachi omume kemịkalụ iji wepụta ike echekwara). A na-ekwu na ihe mgbakwunye Alpha-ketoglutaric acid na-enye ọtụtụ uru ahụ ike, gụnyere arụmọrụ egwuregwu na-arụ ọrụ nke ọma na mmelite metabolism.

Alpha-Ketoglutaric Acid (328-50-7) uru

Site na nke a, obere ọmụmụ ole na ole gosiri na enwere ike ị nweta mgbakwunye alpha-ketoglutaric acid. Nke a bụ ihe ụfọdụ nyocha ọhụụ kwuru:
Ọrịa Akụrụ Na-efe efe
A na-eji Alfa-ketoglutaric acid kemgbe ngwụcha-1990 iji nyere aka ịkụda na ịmịnye protein n'ime ndị mmadụ na hemodialysis chọrọ nri nwere obere protein. Ihe akaebe na-adịbeghị anya na-egosi na ọ nwekwara ike igbu oge mkpa maka dialysis na ndị nwere ọrịa akụrụ na-adịghị ala ala (CKD).

(1) ↗

Isi mmalite

PubMed Central

Ebe nchekwa data a na-akwanyere ùgwù nke ukwuu sitere na National Institutes of Health
Gaa na isi iyi

Dị ka ọmụmụ 2017 na akwụkwọ akụkọ PLoS One si kwuo, ndị nchọpụta chọpụtara ma soro ndị 1,483 nwere CKD dị elu bụ ndị jiri ihe mgbakwunye alpha-ketoglutaric acid na-akpọ Ketosteril. Ogologo oge nke nleba anya bụ afọ 1.57.
N'iji ya tụnyere otu ndị na-anataghị mgbakwụnye ahụ, ndị mere ya adịchaghị achọ dialysis ogologo oge. Uru ndị a gbatịpụrụ naanị ndị were ihe karịrị mbadamba 5.5 kwa ụbọchị, na-egosi nsonaazụ dabere dose.
N'agbanyeghị nchoputa ahụ dị mma, amabeghị ọrụ alpha-ketoglutaric acid na-arụ ma e jiri ya tụnyere ihe mgbakwunye ndị ọzọ na-arụ ọrụ. Achọrọ nyocha ọzọ.

Ahụike Ọrịa
A kwenyere na ihe mgbakwunye Alfa-ketoglutaric acid bụ anticatabolic, nke pụtara na ọ na-ebelata ma ọ bụ na-egbochi ma ọ bụ catabolism (nkwụsị nke anụ ahụ). Site na nkọwa, usoro catabolic na-emegide usoro anabolic (nke a na-ewu anụ ahụ).
Nnyocha e mere na 2012 na Italian Journal of Animal Science kọrọ na alpha-ketoglutaric acid gbochiri mgbawa nke eriri afọ na oke ụlọ nyocha na-eri nri na-enweghị protein maka ụbọchị 14. Kama inwe mmebi na mkpịsị aka dị ka villi nke eriri afọ - ihe a na-atụ anya ya - oke ndị a na-eri nri alpha-ketoglutaric acid enweghị mmebi anya na-ahụ anya ma e jiri ya tụnyere oke ndị na-adịghị.
Ọzọkwa, oke ndị ahụ nyere ihe mgbakwunye nwere ike ịnọgide na-enwe uto nkịtị n'agbanyeghị enweghị protein zuru ezu. A na-enye doses dị elu maka nsonaazụ kacha mma.
Nchọpụta ahụ dị ka ọ na-akwado mmetụta anticatabolic alfa-ketoglutaric acid. Na mgbakwunye na ngwa ya na ọrịa akụrụ na-adịghị ala ala, alfa-ketoglutaric acid nwekwara ike inyere ndị nwere toxemia intestinal aka na ọrịa malabsorption dị ka ọrịa celiac. Achọrọ nyocha ọzọ.

Ọrụ Egwuregwu
N'ụzọ dị iche, mmetụta anticatabolic nke alpha-ketoglutaric acid yiri ka ọ na-adaba mgbe ejiri ya mee ihe maka uto muscle na ịrụ ọrụ egwuregwu.
Dị ka ọmụmụ 2012 si kwuo na Journal of the International Society of Sports Nutrition, alpha-ketoglutaric acid enweghị mmetụta ọ bụla na ike ike ma ọ bụ ntachi obi na ndị ikom 16 na-arụ ọrụ ọzụzụ ọzụzụ ọzụzụ.

(2) ↗

Isi mmalite

PubMed Central

Ebe nchekwa data a na-akwanyere ùgwù nke ukwuu sitere na National Institutes of Health
Gaa na isi iyi

Maka ọmụmụ ihe a, e nyere ọkara nke ndị ikom 3,000-milligrams (mg) nke alpha-ketoglutaric acid, ebe ọkara nke ọzọ ka e nyere placebo 45 nkeji tupu ha emee bench press and leg press exercises. N'izu na-esote, a tụgharịrị ihe mgbakwunye ahụ, ebe ọkara nke ọ bụla na-enweta ọgwụ ọzọ.
Arụmọrụ egwuregwu gbadoro ụkwụ na mkpokọta ibu ibu (TLV) nke mmega ahụ emere n'otu oge yana ọnụego obi tupu yana mmega ahụ mgbe emechara. Ihe nchọpụta ndị a gosipụtara bụ enweghị nzaghachi catabolic abụghị otu ihe dị ka nzaghachi anabolic, karịsịa n'etiti ndị na-eme egwuregwu.

Alpha-Ketoglutaric Acid (328-50-7) jiri?

N'ime ịwa ahụ obi, a na-ebunye alfa-ketoglutaric acid mgbe ụfọdụ n'ime eriri afọ (n'ime akwara) iji belata mmebi nke akwara obi n'ihi mbelata nrịba ọbara. Ime otú ahụ nwekwara ike ime ka ọbara na-eruba na akụrụ na-esochi ịwa ahụ.
Ojiji ya dị ka mgbakwunye adịchaghị nke doro anya. Ndị ọkachamara ọzọ kwenyere na alpha-ketoglutaric acid nwere ike ịgwọ ma ọ bụ gbochie ọnọdụ ahụike dịgasị iche iche, gụnyere:
  • Cataracts
  • -Adịghị ala ala ọrịa akụrụ
  • Hepatomegaly (imeju abawanye)
  • Toxemia eriri afọ
  • Ntughari onu
  • osteoporosis
  • Ahụike
  • Yist na-efe efe
N'ihi ọrụ ya n'ịtọhapụ ike echekwara, a na-erekarị alfa-ketoglutaric acid dị ka mgbakwunye arụmọrụ egwuregwu. Ụfọdụ ndị na-akwado ya na-ekwudị na mmetụta antioxidant nke mgbakwunye ahụ nwere ike belata ịka nká.

(3) ↗

Isi mmalite

PubMed Central

Ebe nchekwa data a na-akwanyere ùgwù nke ukwuu sitere na National Institutes of Health
Gaa na isi iyi

Dị ka ọ na-adịkarị na mgbakwunye na-ekwu na ọ na-agwọ ọtụtụ ọnọdụ na-enweghị njikọ, ihe akaebe na-akwado nkwupụta ndị a adịghị ike. Ụfọdụ, dị ka ihe mgbakwunye "mgbochi ịka nká" (nke dabere na ọmụmụ 2014 metụtara ikpuru nematode), oke na ihe agaghị ekwe omume.

Alfa-Ketoglutaric Acid (328-50-7) usoro onunu ogwu

Ihe mgbakwunye Alfa-ketoglutaric acid dị na mbadamba mbadamba, capsule, na ntụ ntụ na enwere ike ịhụ ya n'ịntanetị ma ọ bụ n'ụlọ ahịa ndị ọkachamara na mgbakwunye nri.
Enweghị ntuziaka zuru ụwa ọnụ maka iji alfa-ketoglutaric acid kwesịrị ekwesị. A na-erekarị mgbakwunye n'ụdị doses sitere na 300 milligrams (mg) ruo 1,000 mg otu ugboro kwa ụbọchị na-eji ma ọ bụ na-enweghị nri. A na-eji doses ruru 3,000 mg na ọmụmụ ihe na-enweghị mmetụta ọjọọ.

Alpha-Ketoglutaric Acid (328-50-7) mmetụta ndị nwere ike

A na-ahụta alfa-ketoglutaric acid dị mma yana nke ọma. Nnyocha na-enyocha mmetụta nke alpha-ketoglutaric acid kọrọ akụkọ ọjọọ ole na ole mgbe afọ atọ ejirichara.
Dị ka ihe mejupụtara sitere na amino acids na-adịghị mkpa, alfa-ketoglutaric acid abụghị ihe ị nwere ike ịdoụbiga mmanya ókè ngwa ngwa. Mfefe ọ bụla n'ime ahụ ka a ga-ewepụ ya na mmamịrị ma ọ bụ gbarie ya n'ime ihe mgbochi amino acid bụ isi maka ebumnuche ndị ọzọ.

(4) ↗

Isi mmalite

PubMed Central

Ebe nchekwa data a na-akwanyere ùgwù nke ukwuu sitere na National Institutes of Health
Gaa na isi iyi

Site na nke ahụ, ewepụtabeghị nchekwa nke alfa-ketoglutaric acid n'ime ụmụ nwanyị dị ime, ndị nne na-enye nwa ara, na ụmụaka. Nke a gụnyere ụmụaka nwere nsogbu metabolism na-adịghị ahụkebe dị ka ụkọ alfa-ketoglutarate dehydrogenase (nke ọkwa alfa-ketoglutaric acid na-ebuli elu nke ukwuu).

Alpha-Ketoglutaric Acid ntụ ntụ maka ire ere (Ebee Ka Alphazụta Alpha-Ketoglutaric Acid na nnukwu)

Companylọ ọrụ anyị na ndị ahịa anyị na-enwe mmekọrịta ogologo oge n'ihi na anyị na-elekwasị anya n'ọrụ ndị ahịa ma na-enye nnukwu ngwaahịa. Ọ bụrụ na ị nwere mmasị na ngwaahịa anyị, anyị na-agbanwe agbanwe na nhazi nke iwu iji kwekọọ na mkpa gị kpọmkwem na oge ngwụsị nke oge anyị na ntinye iwu nke nkwa ị ga-enwe nnukwu uto nke ngwaahịa anyị n'oge. Anyị na-elekwasịkwa anya n'ọrụ bara uru. Anyị dị maka ajụjụ ọrụ na ozi iji kwado azụmahịa gị.
Anyị bụ ndị ọkachamara Alpha-Ketoglutaric Acid ntụ ntụ soplaya ruo ọtụtụ afọ, anyị na-enye ngwaahịa na ọnụahịa asọmpi, na ngwaahịa anyị bụ nke kachasị mma ma na-anwale ule siri ike, nke onwe ya iji hụ na ọ dị mma maka oriri gburugburu ụwa.

Ntughari:

  1. Abrahams JP, Leslie AG, Lutter R, Walker JE. Nhazi na 2.8 Mkpebi nke F1-ATPase si na bovine obi mitochondria. Nature. 1994; 370: 621–628. ma ọ bụ: 10.1038 / 370621a0.
  2. Alpers DH. Glutamine: ihe data ahụ na-akwado ihe kpatara ntinye glutamine na ụmụ mmadụ? Ọrịa. 2006; 130: S106 – S116. ma ọ bụ: 10.1053 / j.gastro.2005.11.049.
  3. Ashkanazi J, Carpertier Y, Michelsen C. Akwara na plasma amino acid na-eso mmerụ ahụ. Ann Surg. 1980; 192: 78–85. ma ọ bụ: 10.1097 / 00000658-198007000-00014.