Ọdịdị nke ketoglutaric

Cofftek nwere ikike imepụta ihe na ịnye Calcium 2-oxoglutarate na Alpha-Ketoglutaric Acid n'okpuru ọnọdụ nke cGMP.

Gịnị bụ Alfa-Ketoglutaric Acid (328-50-7)?

Alfa-ketoglutaric acid bu ihe ndi ozo n’ahu n’ime aru mmadu. Nakwa dị ka ihe oriri na-edozi ahụ, alpha-ketoglutaric acid na-arụ ọrụ dị mkpa na okirikiri Krebs (usoro mmeghachi omume kemịkalụ iji wepụta ike echekwara). A na-ekwu na ihe mgbakwunye Alpha-ketoglutaric acid na-enye ọtụtụ uru ahụ ike, gụnyere arụmọrụ egwuregwu na-arụ ọrụ nke ọma na mmelite metabolism.

Alpha-Ketoglutaric Acid (328-50-7) uru

Site na nke a, obere ọmụmụ ole na ole gosiri na enwere ike ị nweta mgbakwunye alpha-ketoglutaric acid. Nke a bụ ihe ụfọdụ nyocha ọhụụ kwuru:
Ọrịa Akụrụ Na-efe efe
Ejirila Alpha-ketoglutaric acid kemgbe mbubreyo 1990 iji nyere aka gbarie na ịmịkọrọ protein na ndị mmadụ na hemodialysis ndị chọrọ nri protein dị ala. Ihe akaebe na-egosi na ọ nwere ike igbu oge maka ịrịa ọrịa na ndị nwere ọrịa akụrụ na-adịghị ala ala (CKD). Dabere na nyocha nke 2017 na akwụkwọ akụkọ PLoS One, ndị nchọpụta chọpụtara ma soro ndị 1,483 nwere CKD dị elu bụ ndị jiri mgbakwunye mkpụrụ alpha-ketoglutaric akpọrọ Ketosteril. Ogologo oge nke ntinye ahụ bụ afọ 1.57. E jiri ya tụnyere otu ndị jikọtara ọnụ na-anaghị ewere mgbakwunye, ndị mere obere nwere ike ịchọ ịrịa ọrịa dị ogologo oge. Uru ndị a na-erubere nanị ndị na-ewere ihe karịrị mbadamba 5.5 kwa ụbọchị, na-egosi na mmetụta ndị ahụ na-adabere na dose. N’agbanyeghi nchoputa di nma, amataghi udiri alpha-ketoglutaric acid di ka ihe eji eme ihe ndi ozo. Ọ dị mkpa nyocha ọzọ.

Ahụike Ọrịa
A na-ekwenye na mgbakwunye Alpha-ketoglutaric acid bụ anticatabolic, nke pụtara na ọ na-ebelata ma ọ bụ na-egbochi ma ọ bụ catabolism (mmebi nke anụ ahụ). Site na nkọwa, usoro catabolic na-abụghị usoro anabolic (nke a na-ewu anụ ahụ). Nnyocha e mere na 2012 na Akwụkwọ akụkọ Italian nke Animal Science kọrọ na alpha-ketoglutaric acid gbochiri mmebi nke eriri afọ na oke nyocha na-enye nri na-enweghị protein maka ụbọchị 14. Kama inwe mmebi nke mkpịsị aka nke dịka eriri afọ nke eriri afọ-nsonaazụ a tụrụ anya ya - oke ndị ahụ nyere alpha-ketoglutaric acid enweghị mmebi a na-ahụ anya ma e jiri ya tụnyere oke na-adịghị. Ọzọkwa, oke ndị ahụ nyere ihe mgbakwunye ahụ nwere ike ịnọgide na-eto eto n'agbanyeghị enweghị protein. Ngwunye dị elu ka enyere ọbụna nsonaazụ kacha mma. Ihe nchoputa a gosiputara na-akwado nsogbu ogwu alpha-ketoglutaric acid. Na mgbakwunye na ntinye ya na ọrịa akụrụ na-adịghị ala ala, alpha-ketoglutaric acid nwekwara ike inyere ndị nwere ọrịa toxemia nsị na ọrịa malabsorption aka dị ka ọrịa celiac. Ọ dị mkpa nyocha ọzọ.

Ọrụ Egwuregwu
N'ụzọ dị iche, mmetụta nke anticatabolic nke alpha-ketoglutaric acid na-ada ka ọ na-ada ada mgbe ejiri ya maka ebumnuche nke uto ahụ na egwuregwu. Dabere na nyocha nke 2012 na Journal of the International Society of Sports Nutrition, alpha-ketoglutaric acid enweghị mmetụta pụtara ìhè na ike ike ma ọ bụ nwee ntachi obi na ụmụ nwoke 16 na-arụ ọrụ mgbatị ahụ. Maka ọmụmụ ihe a, e nyere ọkara nke ndị nwoke 3,000-milligrams (mg) nke alpha-ketoglutaric acid, ebe ọkara nke ọzọ nyere placebo minit 45 tupu ha eme egwuregwu pịa na mgbatị ụkwụ. N’izu na-eso ya, a gbanwere ihe mgbakwunye ahụ, ọkara nke ọ bụla na-enweta ọgwụ ọzọ. Egwuregwu na-adabere na mkpokọta ibu ibu (TLV) nke mmega ahụ emere na tandem yana tupu na mmega ahụ mgbatị obi. Ihe nchọpụta ndị a gosipụtara bụ na enweghị catabolic nzaghachi abụghị otu ihe dịka nzaghachi anabolic, karịsịa n'etiti ndị na-eme egwuregwu.

Alpha-Ketoglutaric Acid (328-50-7) jiri?

N'ime ịwa ahụ obi, a na-enyefe mkpụrụ ọgwụ alpha-ketoglutaric mgbe ụfọdụ (n'ime akwara) iji belata mmebi nke akwara obi n'ihi mbenata ọbara na-ebelata. Ime nke a nwekwara ike ime ka ọbara gbasaa na akụrụ na-esote ịwa ahụ. Ojiji ya dika mgbakwunye bu ihe doro anya. Ndị ọkachamara ọzọ kwenyere na alpha-ketoglutaric acid nwere ike ịgwọ ma ọ bụ gbochie ọtụtụ ọnọdụ ahụike, gụnyere:
  • Cataracts
  • -Adịghị ala ala ọrịa akụrụ
  • Hepatomegaly (imeju abawanye)
  • Toxemia eriri afọ
  • Ntughari onu
  • osteoporosis
  • Ahụike
  • Yist na-efe efe
N'ihi ọrụ ya na ịhapụ ike echekwara, a na-erekarị alpha-ketoglutaric acid dị ka mgbakwunye arụmọrụ egwuregwu. Somefọdụ ndị na-akwado ya na-ekwusi ike na mgbakwunye antioxidant a na-agbakwunye nwere ike belata ịka nká. Dị ka ọ na-adịkarị na mgbakwunye na-ekwu na ha na-emeso ọtụtụ ọnọdụ ndị na-enweghị njikọ, ihe akaebe na-akwado nkwupụta ndị a adịghị ike. Fọdụ, dị ka ihe mgbakwunye nke "mgbochi ịka nká" (dabere n'ụzọ dị ukwuu na nyocha 2014 metụtara ikpuru nematode), ókè na-agaghị ekwe omume.

Alfa-Ketoglutaric Acid (328-50-7) usoro onunu ogwu

Ihe mgbakwunye Alpha-ketoglutaric acid dị na mbadamba, capsule, na ntụ ntụ nwere ike ịchọta ngwa ngwa n'ịntanetị ma ọ bụ n'ụlọ ahịa ndị ọkachamara na mgbakwunye nri. Enweghị ụkpụrụ nduzi ụwa maka iji ojiji alpha-ketoglutaric kwesịrị ekwesị. Ihe mgbakwunye na-erekarị na usoro onunu sitere na 300 milligrams (mg) na 1,000 mg were otu ugboro kwa ụbọchị ma ọ bụ na-enweghị nri. Ejirila ihe ruru 3,000 mg na ọmụmụ ihe na enweghị nsogbu ọ bụla.

Alpha-Ketoglutaric Acid (328-50-7) mmetụta ndị nwere ike

A na-ahụta Alpha-ketoglutaric acid dị ka ihe dị mma ma na-anabata ya nke ọma. Nnyocha na-enyocha mmetụta nke alpha-ketoglutaric acid kọrọ ọtụtụ ihe mgbaàmà na-adịghị mma mgbe afọ atọ gasịrị. Dị ka onyinye sitere na amino acid na-adịghị mkpa, alpha-ketoglutaric acid abụghị ihe ị ga - eri ngwa ngwa. Nbubata ọ bụla n'ime ahụ ga - ewepụ na mmamịrị ma ọ bụ gbasaa n'ime isi amino acid maka nzube ndị ọzọ. Site na nke a, echebeghị nchekwa nke alpha-ketoglutaric acid na ụmụ nwanyị dị ime, ndị nne na-enye nwa, na ụmụaka. Nke a gụnyere ụmụaka nwere obere nsogbu metabolism dị ka ụkọ alpha-ketoglutarate dehydrogenase (nke alpha-ketoglutaric acid dị elu).

Alpha-Ketoglutaric Acid ntụ ntụ maka ire ere (Ebee Ka Alphazụta Alpha-Ketoglutaric Acid na nnukwu)

Companylọ ọrụ anyị nwere mmekọrịta mmekọrịta ogologo oge na ndị ahịa anyị n'ihi na anyị na-elekwasị anya na ọrụ ndị ahịa na inye nnukwu ngwaahịa. Ọ bụrụ na i nwere mmasị na anyị ngwaahịa, anyị na-agbanwe na customization nke iwu ona gị kpọmkwem mkpa na anyị ngwa ngwa ụzọ oge na iwu emesi ị ga-enwe oké akatabi okop ngwaahịa anyị na-oge. Anyị na-elekwasịkwa anya na ọrụ ndị bara uru. Anyị dị maka ajụjụ ọrụ na ozi iji kwado azụmahịa gị. Anyị bụ ọkachamara ọkachamara-Alpha-Ketoglutaric Acid na-ebu ngwaahịa ọtụtụ afọ, anyị na-enye ngwaahịa na asọmpi ọnụahịa, ngwaahịa anyị kachasị mma ma na-anwale ule siri ike, nke onwe iji hụ na ọ dị mma maka oriri gburugburu ụwa.

Ntughari:

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  2. Alpers DH. Glutamine: ihe data ahụ na-akwado ihe kpatara ntinye glutamine na ụmụ mmadụ? Ọrịa. 2006; 130: S106 – S116. ma ọ bụ: 10.1053 / j.gastro.2005.11.049.
  3. Ashkanazi J, Carpertier Y, Michelsen C. Akwara na plasma amino acid na-eso mmerụ ahụ. Ann Surg. 1980; 192: 78–85. ma ọ bụ: 10.1097 / 00000658-198007000-00014.