Urolithin ntụ ntụ

Cofftek nwere ikike imepụta ihe na inye urolithin a na urolithin b n'okpuru ọnọdụ cGMP.

Okwu Mmalite na Urolithins

Urolithins bụ metabolites nke abụọ nke ellagic acid sitere na ellagitannins. N'ime mmadụ ellagitannins na-agbanwe site na gut microflora n'ime ellagic acid nke na-agbanwe ọzọ n'ime urolithins A, urolithin B, urolithin C na urolithin D na nnukwu eriri afọ.

Urolithin A (UA) bụ ihe kachasị emetụta metabolite nke ellagitannins. Agbanyeghị, urolithin A amaghi na ọ na-eme n'ụzọ nkịtị na usoro nri ọ bụla.

Urolithin B (UB) bu ihe omuma di uku nke emeputara n'ime ime site na mgbanwe nke ellagitannins. Urolithin B bu nke ikpeazu mgbe emechara urolithin ndi ozo. Urolithin B dị na mmamịrị dị ka urolithin B glucuronide.

  Urolithin A 8-Methyl Ether bụ ngwaahịa dị n'etiti n'etiti njikọ nke Urolithin A. Ọ bụ nnukwu metabolite nke abụọ nke ellagitannin ma nwee antioxidant na mgbochi mkpali Njirimara.

Usoro nke urolithin A na B

Rol Urolithin A na - ebute mitophagy
Mitophagy bụ otu ụdị arụrụ aka nke na - enyere aka wepu mitochondrial mebiri emebi maka ọrụ ha kachasị mma. Autophagy na-ezo aka na usoro izugbe nke ihe cytoplasmic mebiri emebi ma na-ejikwa ya emegharị mgbe mitophagy bụ mbibi na nrụgharị nke mitochondria.

N'oge ịka nká, mbelata nke autophagy bụ otu akụkụ na-eduga n'ịbelata ọrụ mitochondrial. Ọzọkwa, nrụgide oxidative nwekwara ike iduga obere autophagy. Urolithin A nwere ikike iwepu mitochondria mebiri emebi site na nhọrọ autophagy.

Njirimara antioxidant
Oxidative nrụgide na-eme mgbe enwere nghọtahie n'etiti radicals free na antioxidant dị na ahụ. Ihe ndi a n’emebi ihe n’emeghị nsogbu n’obi na-ejikọkarị ya na ọtụtụ ọrịa na-adịghị ala ala dịka ọrịa obi, ọrịa shuga na kansa.

Urolithins A na B na-egosipụta mmetụta antioxidant site na ikike ha iji belata radicals n'efu yana otu ọkwa oxygen intracellular reactive nke mkpụrụ ndụ (ROS) ma na-egbochi mkpụrụ ndụ peroxidation n'ụdị ụfọdụ.

Ọzọkwa, urolithins nwere ike igbochi ụfọdụ enzymes na-egbu egbu, gụnyere monoamine oxidase A na tyrosinase.

● Njirimara mgbochi
Mbufụt bụ usoro okike nke ahụ anyị na-alụ ọgụ megide ihe ọ bụla dara ada dị ka ọrịa, mmerụ ahụ, na ụmụ nje. Agbanyeghị, mbufụt na-adịghị ala ala nwere ike bụrụ ihe na-emerụ ahụ n'ihi na enwere nsogbu dị iche iche dịka ụkwara ume ọkụ, nsogbu obi, na kansa. Ọrịa na-adịghị ala ala nwere ike ime n'ihi nnukwu ọnya na-enweghị ọgwụgwọ, ọrịa ma ọ bụ ọbụna ihe na-akpata free na ahụ.

Urolithins A na B na-egosipụta ihe mgbochi mbufụt site na igbochi mmepụta nitric oxide. Ha na egbochi ọgwụ nitric oxide synthase (iNOS) inducible na mRNA nke na-ahụ maka mbufụt.

Effects Mmetụta nje na-alụso nje ọgụ
Besmụ nje gụnyere nje, fungi na nje na-ewere ọnọdụ na gburugburu ebe obibi yana n'ahụ mmadụ. Agbanyeghị, ụmụ nje ole na ole akpọrọ ọrịa nje nwere ike ibute ọrịa na-efe efe dị ka flu, ọrịa na ọrịa ịba.

Urolithin A na B nwere ike igosipụta mmeghachi omume antimicrobial site na igbochi sensor quorum. Orchọpụta Quorum bụ usoro nkwukọrịta nke nje na-enyere nje aka ịchọpụta na ịchịkwa usoro metụtara ọrịa dịka virulence na motility.

Hib Imechi glycation protein
Glycation na-ezo aka na njikọ nke shuga na-enweghị enzymatic. Ọ bụ akara biomarker na ọrịa shuga na nsogbu ndị ọzọ yana ịka nká.

Nnukwu protein protein bụ mmetụta nke abụọ nke hyperglycemia nwere ọrụ dị ukwuu na nsogbu metụtara ọrịa obi dịka ọrịa shuga na ọrịa Alzheimer.

Urolithin A na B nwere ihe ndị na-egbochi glycative nke nwere ọgwụ ndabere dabere na-akwụghị ụgwọ ọrụ antioxidant ha.

Urolithin A na nke B na-erite uru

Urolithins nwere ọtụtụ mmetụta bara uru na-akwado site na ihe akaebe sitere na nyocha nke mgbochi mkpali, anti-carcinogenic, antioxidant, and antimicrobial properties. Urolithin A uru nwere njikọ chiri anya na uru urolithin B. N'okpuru bụ ụfọdụ uru ndị a kọrọ site na urolithins;
Urolithin A uru
(1) Nwere ike ịgbatị oge ndụ
Urolithin A na - akpata mitophagy site na iwezuga mitochondria mebiri emebi. Nke a na - asuresụrị nrụgharị nke mitochondria maka ịrụ ezigbo ọrụ. Mitochondria na-emebi ọtụtụ oge yana afọ yana n'ihi nrụgide. Ridchụpụ mitochondria mebiri emebi na-ekere òkè n'ịgbatịkwu afọ ndụ gị.

Na nyocha nke ikpuru, urolithin Ihe ndozi nke enyere na 50 µM site na akwa akwa ruo ọnwụ hụrụ ka ọ na-agbatị ndụ ha site na 45.4%.

N'ọmụmụ ihe ọzọ emere na 2019 n'iji fibroblasts senescent mmadụ, urolithin A mgbakwunye achọtara iji gosipụta ikike ịka nká. Ọ nwere ike ịbawanye okwu 1 nke collagen ma belata ngosipụta nke matriks metalloproteinase 1.

Obere ihe omumu mmadu gosiputara na UA nwere ike meziwanye oru mitochondrial na ahuike ndi mmadu n’egwuregwu mgbe ejiri onu me ya na 500-1000mg rue oge izu anọ.

(2) Nyere aka igbochi kansa prostate
Urolithins na njiri mara ha, ellagitannins, nwere ihe eji egbochi ọrịa kansa. Ha nwere ike igbochi mgbasa mkpụrụ ndụ kansa site na njide sel na ịbanye apoptosis. Apoptosis na-ezo aka na ọnwụ mkpụrụ ndụ nke ahụ mmadụ kpochapụrụ mkpụrụ ndụ cancer nwere na mkpụrụ ndụ ndị ọzọ nwere ọrịa.

Na nyocha nke ụmụ oke ji mkpụrụ ndụ kansa, ellagitannins metabolites (Urolithin A) chọpụtara na igbochi uto nke ọrịa kansa. Ọmụmụ ihe ahụ kọwakwara mkpara nke metabolites dị na gland prostate, muscle na anụ ahụ.

(3) Mmuta mmuta
Urolithin A nwere ike ichebe neurons site na ọnwụ ma nwee ike ịkpalite neurogenesis site na akara ngosi mgbochi mkpali.

N'ime ihe omumu banyere oke okike, a chọpụtara urolithin A ka oke ghara inwe nchekwube ma chekwaa neurons site na apoptosis. Nke a na-egosi na enwere ike iji UA na-agwọ ọrịa Alzheimer (AD).

(4) Imegide oke ibu
Nchọpụta e mere gosiri na ellagitannins na-enwe ike igbochi nnụchi egbugbere ọnụ yana ihe nrịbama ọrịa adipogenic dịka protein uto nke uto 2 yana protein na-ejikọ aka site na njide sel.

Achọpụtala Urolithin A ka ọ rụọ ọrụ iji mee ka insulin mara mma si otú a gbochie mmepe nke oke ibu.

Na nyocha nke ụmụ oke na oke ibu, urolithin A hụrụ mgbakwunye iji gbochie oke ibu oke ibu nri na oke mmezi nke ụmụ oke. Ọmụmụ ihe ahụ gosiri na ọgwụgwọ nke UA mụbara mmefu ike n'ihi ya ọ nwere oke ahụ.

Urolithin B bara uru
Ihe mgbakwunye Urolithin B nwekwara ọtụtụ uru ahụike yana ọtụtụ n'ime ya yiri uru urolithin A.

(1) Mgbochi ọrịa kansa
Ngwongwo mgbochi nke urolithin B na-eme ka ọ bụrụ ezigbo nwa akwukwo maka ịlụ ọgụ cancer. Researchersfọdụ ndị nyocha akọpụtala ike ha na fibroblasts, microphages na sel sel endothelial.

Nnyocha e mere egosiwo na UB na-egbochi ụdị ọrịa kansa dị iche iche dịka prostate, colon na cancer eriri afọ.

N'ime nyocha metụtara mkpụrụ ndụ cancer mmadụ, ellagitannins, ellagic acid na urolithins A na B ka enyocha maka ikike ha nwere ịlụ ọgụ cancer. Ha kọrọ na usoro ọgwụgwọ niile nwere ike igbochi uto nke mkpụrụ ndụ kansa. Ha gbochiri ịgbatị mkpụrụ ndụ kansa site na njide sel mkpụrụ ndụ na ọkwa dị iche iche yana site na itinye apoptosis.

(2) Nwere ike inye aka ịlụ ọgụ megide nrụgide oxidative
Urolithin B nwere ezigbo antioxidant Njirimara site na mbenata ikuku oxygen na-arụ ọrụ na lipid peroxidation na ụfọdụ cell ụdị. A na-ejikọta ọkwa dị elu nke ROS na ọtụtụ nsogbu dịka ọrịa Alzheimer.

N'ime ọmụmụ ya na mkpụrụ ndụ neuronal kpughere na nchekasị oxidative, a hụrụ urolithin B yana yana urolithin A chebe sel iji gbochie oxidation ya mere mụbara mkpụrụ ndụ.

(3) Urolithin B na ebe nchekwa
A kọwo Urolithin b iji meziwanye ikike mgbochi ọbara. Nke a na - eme ka ọgụgụ isi rụọ ọrụ.

Mmụta emere gosiri na urolithin B nwere ike bụrụ ihe nkwalite nchekwa site na imeziwanye ọrụ ọgụgụ isi.

(4) Na-egbochi iku ume
Ọnwụ anụ ahụ nwere ike ime n’ihi ọtụtụ ebumnuche dịka ọgba aghara, ịka nká na ụkọ protin n’ime nri. Ọtụtụ usoro iji kwụsị, ike ma ọ bụ gbochie mfu anụ ahụ gụnyere, mmega ahụ, ọgwụ na amino acid yana polyphenols nwere ike ịrụ ọrụ.

Enwere ike eke urolithins dị ka polyphenols ma rụọ ọrụ na igbochi mfu muscle site na-eme ka njikọta protein protein na-emekwa ka ọ daa n'iyi.

N'ime ọmụmụ ya na ụmụ oke, achọtara Urolithin B na-elekọta ihe karịrị oge iji mee ka mmepe akwara dịwanye elu ka a hụrụ ka uru ahụ na-abawanye.  

(5) Urolithin B na-alụ ọgụ megide mbufụt
Urolithin B nwere ihe mgbochi mbufụt site na mbenata ihe nrịbama mbufụt.

 N'ime ọmụmụ nke oke nwere ọrịa akwara na-akpata akwara, a hụrụ urolithin B iji belata mmerụ akụrụ. Ọ welie ọrụ gbasara akụrụ, morphology nke akụrụ yana belata akara mmerụ akwara. Nke a na-egosi na UB nwere ike igbochi mbufụt gbasara akụrụ.

(6) Uru uru nke urolithin A na B
Enweela mmetụta nke mmekọrịta mmekọrịta na nchikota urolithin A na B na arụ ọrụ na ikike. Ọmụmụ ihe ahụ kwuru na enwere ike iji nchikota a gwọọ ma ọ bụ gbochie nsogbu metụtara mgbaka dịka nchekasị ma ọ bụ ọrịa Alzheimer.

Uru ndị ọzọ metụtara urolithins bụ;
  • neuroprotection
  • Na-agwọ ọrịa metabolic

Urolithin A na nri nri B

A maghị Urolithins n'ụzọ nkịtị na isi nri ọ bụla. Ha bụ ngwaahịa nke mgbanwe nke ellagic acid nke a na - enweta site na ellagitannins. A na-agbanwe Ellagitannins ka ọ bụrụ acids ellagic site na gita microbiota ma a na-agbanyekwu ọkụ acid n'ime metabolites (urolithins) na nnukwu eriri afọ.

  Ellagitannins na-apụtakarị na isi mmalite nri dị ka pọmigranet, mkpụrụ osisi gụnyere mkpụrụ osisi strawberries, raspberries, Cloudberries na blakberị, mkpụrụ osisi muscadine, almọnd, guavas, tii, na mkpụrụ ndị dị ka walnuts na chestnuts yana mmanya na-eme agadi maka ihe atụ mmanya na-acha ọbara ọbara na whiskey si nnukwu osisi.

Ya mere anyi nwere ike ikwubi urolithin A nri na urolithin B nri bu nri ellagitannin bara ọgaranya. Okwesiri ighota na ellagitannin bioavailability nwere oke oke ebe ihe omuma ya nke abuo (urolithins) di ngwa ngwa.

Urolithins excretion na mmepụta dịgasị iche n'etiti ndị mmadụ ebe ọ bụ na ntụgharị si ellagitannins na-adabere na microbiota na eriri afọ. Enwere nje bacteria a kapịrị ọnụ na ntụgharị a ma dịgasị iche n'etiti ndị mmadụ ebe ụfọdụ nwere microbiota kwesịrị ekwesị, ma ọ bụ obere dị. Ebe nri dị iche iche dịkwa iche iche na ogo ellagitannins. N'ihi ya, uru bara uru nke ellagitannins dịgasị iche site n'otu onye gaa na nke ọzọ.

Urolithin A na B Mgbakwunye

Urolithin A mgbakwunye yana Urolithin B mgbakwunye na-achọta ngwa ngwa n'ahịa dị ka mgbakwunye mgbakwunye nri ellagitannin. Urolithin A Mmeju nwekwara ngwa ngwa. Karịsịa pọmigranet Mmeju e rere ọtụtụ ebe na-eji na-aga nke ọma. Ihe mgbakwunye ndị a na-esite na mkpụrụ osisi ma ọ bụ mkpụrụ wee mepụta ha mmiri ma ọ bụ ntụ ntụ.

N'ihi ọdịiche dị na nri ellagitannins na nri dị iche iche, ndị ahịa nke urolithin zụta ya na-echebara isi iyi nri. Otu ihe a na - emetụta mgbe ị na - agbakwunye urolithin B ntụ ntụ ma ọ bụ mmeju mmiri.

Ihe omumu omumu mmadu nke ejiri urolithin A uzuzu ma obu B emeghi ihe obula banyere nsogbu ndi ozo.

Ntughari:

  1. Garcia-Muñoz, Cristina; Ogwu, Fabrice (2014-12-02). "Ọnọdụ Metabolic nke Ellagitannins: Mmetụta maka Ahụ Ike, na Atụmatụ Nchọpụta Maka Nri Na-arụ Ọrụ Na-agbanwe agbanwe". Nyocha dị oke egwu na Science Food na Nutrition.
  2. Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (11 Nọvemba 2009). "Urolithins, eriri afọ microbial metabolites nke Pomegranate ellagitannins, na-egosipụta ike ọrụ antioxidant na nnwale dabere na cell". J Agric Nri Chem.
  3. Bodwell, Graham; Pottie, Ian; Nandaluru, Penchal (2011). "Onyinye Electron Na-achọghị Mmegharị-Alder-based Total Synthesis of Urolithin M7".