Alfa Lipoic Acid (ALA) (1077-28-7) Smmezi

aha:	Alfa Lipoic Acid (ALA)
CAS:	1077-28-7
ọcha	98%
Usoro Molecular:	C8H14O2S2
Molekụla arọ:	206.33 g / mol
Melt Point:	60 – 62 ° C (140 – 144 ° F; 333 – 335 K)
Aha aha:	(R) -5- (1,2-Dithiolan-3-yl) pentanoic acid dị; α-Lipoic acid; Alfa lipoic acid; Thioctic acid; 6,8-Dithiooctanoic acid
Synonyms:	(±) -α-Lipoic acid, (±) -1,2-Dithiolane-3-pentanoic acid, 6,8-Dithiooctanoic acid, DL -α-Lipoic acid, DL -6,8-Thioctic acid, egbugbere ọnụ (S2) )
KeyInChI:	AGBQKNBQESQNJD-UHFFFAOYSA-N
Ọkara ndụ:	Ọkara ndụ nke eji ọnụ ekwu okwu ALA bụ naanị 30 min
Solubility:	Nnọọ obere soluble na mmiri (0.24 g / L); Solubility na ethanol 50 mg / mL
Ọnọdụ Nchekwa:	0 - 4 C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 C maka ogologo oge (ọnwa)
ngwa:	A na-eji Alpha-lipoic acid mee ihe n’ahụ iji mebie carbohydrates na ike maka akụkụ ndị ọzọ dị n’ime ahụ. Alfa-lipoic acid yiri ka ọ na-arụ ọrụ dị ka antioxidant, nke pụtara na ọ nwere ike ichebe ụbụrụ n'okpuru ọnọdụ mmebi ma ọ bụ mmerụ ahụ.
anya:	Yellow-yiri kristal

Alfa Lipoic Acid (ALA) (1077-28-7) NMR ụdịdị dị iche iche

Alfa Lipoic Acid (ALA) (1077-28-7) - NMR ụdịdị dị iche iche

Ọ bụrụ na ịchọrọ COA, MSDS, HNMR maka ụdị ngwaahịa ọ bụla na ozi ndị ọzọ, biko kpọtụrụ anyị njikwa ahia.

Alfa Lipoic Acid (ALA) (1077-28-7)?

Alfa-lipoic acid bu ihe anahu anya n’ime sel obula nke aru mmadu. Isi ọrụ ya bụ ịgbanwe shuga shuga (glucose) n'ime ike site na iji oxygen, usoro a na-akpọ dị ka metabolism aerobic. A na-ahụkwa Alpha-lipoic acid dị ka ihe na-egbu egbu, nke pụtara na ọ nwere ike iwepu ogige ndị na-emerụ ahụ a na-akpọ radicals free nke na-emebi mkpụrụ ndụ na mkpụrụ ndụ mkpụrụ ndụ.

Ihe na-eme alpha-lipoic acid pụrụ iche bụ na ọ nwere ike ịgbanye na mmiri na abụba. Nke ahụ pụtara na ọ nwere ike ịnapụta ike ozugbo ma ọ bụ chekwaa ya maka ojiji n'ọdịnihu.

Alfa-lipoic acid nwekwara ike imegharị antioxidants "eji", gụnyere vitamin C, vitamin E, na nnukwu amino acid nke a maara dị ka glutathione.1 Mgbe ọ bụla antioxidants a na-egbochi radical free, ha na-agbagha ma bụrụ ndị na-enweghị onwe ha. Alpha-lipoic acid na-enyere aka weghachite ha site na ịmịkọrọ elektrọn karịrị akarị ma gbanwee ha azụ azụ n'ụdị ha kwụsiri ike.

Mgbe ụfọdụ, a na-ewere Alpha-lipoic acid dị ka mgbakwunye n'okpuru nkwenye ọ nwere ike melite ụfọdụ ọrụ metabolic, gụnyere ịba abụba, mmepụta collagen, na njikwa glucose ọbara. Enwere ihe akaebe na-eto eto nke opekata mpe nkwupụta ndị a.

Alfa Lipoic Acid (ALA) (1077-28-7) uru

Diabetes

Ọ dịla anya echere na alpha-lipoic acid nwere ike inye aka na njikwa glucose site na ịbawanye ọsọ nke na-eme ka ọbara shuga na-emetụta. Nke a nwere ike inye aka n'ịgwọ ọrịa shuga, ọrịa nke oke ogo glucose ọbara dị elu.

Nyocha 2018 na nyocha-nyocha nke 20 ọnwụnwa a na-achịkwa nke ndị mmadụ na-arịa ọrịa metabolic (ụfọdụ nwere ụdị ọrịa shuga 2, ndị ọzọ nwere nsogbu ndị ọzọ metabolic) chọpụtara na mgbakwunye lipoic acid gbadara glucose ọbara na-ebu ọnụ, ịchekwa insulin, insulin resistance, na ọbara haemoglobin A1C ọkwa.

Akwara mgbu

Neuropathy bụ okwu ahụike eji kọwaa ihe mgbu, ụfụ, na mmetụta na-adịghị mma nke mmebi akwara kpatara. Ọtụtụ mgbe, mmebi ahụ na-akpata site na nrụgide oxidative na-etinye na akwara site na ọrịa ndị na-adịghị ala ala dịka ọrịa shuga, ọrịa Lyme, shingles, ọrịa thyroid, akụrụ akụrụ, na nje HIV.

Somefọdụ kwenyere na mkpụrụ alpha-lipoic, nke enyere n'ọtụtụ buru ibu, nwere ike ịkwụsị nrụgide a site na ịrụ ọrụ antioxidant siri ike. Enweela ihe akaebe nke mmetụta a na ndị nwere ọrịa shuga na-arịa ọrịa shuga, ọnọdụ nwere ike ịda mbà na-arịa ndị nwere ọrịa shuga dị elu.

Ntụleghachi nke ọmụmụ ihe ọmụmụ 2012 sitere na Netherlands kwubiri na ọgwụ kwa ụbọchị nke mkpụrụ ọgwụ 600-mg nke mkpụrụ ọgwụ alpha-lipoic a na-enye ihe karịrị izu atọ na-eweta “mbelata na mkpa ọgwụgwọ dị mkpa nke mgbu neuropathic.”

Dị ka ọ dị na ọmụmụ ọrịa shuga gara aga, alfa-lipoic acid ọnụ Mmeju na-adịkarị obere irè ma ọ bụ enweghị mmetụta ọ bụla.

ibu Loss

Alfa-lipoic acid nwere ike ịkwalite ọkụ kalori ma kwalite arọ ọnwụ ọtụtụ ndị gurus na ndị na-emepụta ihe na-emepụta nri na-ekwubiga okwu ókè. N'ikwu nke ahụ, enwere ihe akaebe na-eto eto na alfa-lipoic acid nwere ike imetụta ịdị arọ, n'agbanyeghị na ọ dị nro.

Nnyocha ọmụmụ nke 2017 sitere na Mahadum Yale chọpụtara na mgbakwunye alfa-lipoic acid, nke sitere na 300 ruo 1,800 mg kwa ụbọchị, nyere aka mee ka nkezi. arọ ọnwụ nke 2.8 pound ma e jiri ya tụnyere placebo.

Enweghị njikọ n'etiti mgbakwunye alfa-lipoic na ọnụọgụ nke arọ ọnwụ. Ọzọkwa, oge ọgwụgwọ na-egosi na ọ na-emetụta ọnụọgụ ahụ mmadụ (BMI), mana ọ bụghị ibu onye ahụ n'ezie.

Ihe nke a pụtara bụ na, ọ bụ ezie na ọ dị ka ị nwere ike iburu ibu dị ukwuu na alpha-lipoic acid, ahụ gị nwere ike ịka mma ka abụba ji nwayọọ nwayọọ dochie abụba.

Cholesterol dị elu

Alfa-lipoic acid dị ogologo oge ekwere na ọ na-emetụta ibu na ahụike site na ịgbanwe mkpo abụba (abụba) n'ime ọbara. Nke a na - agụnye cholesterol dị “mma” dị elu (HDL) na-abawanye oke ma nwekwaa cholesterol na triglycerides nke “adịghị mma”. Nnyocha e mere na nso nso a na-egosi na nke a nwere ike ọ gaghị adị otú ahụ.

N'ime nnyocha 2011 sitere na Korea, ndị okenye 180 nyere 1,200 ka 1,800 mg nke alpha-lipoic acid kwụsịrị 21 pasent karịa ibu karịa otu placebo mgbe izu 20 gachara mana enweghị mmụba ọ bụla na cholesterol zuru ezu, LDL, HDL, ma ọ bụ triglycerides.

N'ezie, ọnụọgụ dị elu nke alpha-lipoic acid nyere ka mmụba na mkpokọta cholesterol na LDL na ndị na-amụ ihe.

Akpụkpọ Anyanwụ Na-emebi

Ndị na-emepụta ihe ịchọ mma na-amasịkarị ịnya isi na nke ha ngwaahịa na-erite uru site na njirimara "mgbochi ịka nká" nke alfa-lipoic acid. Nnyocha na-egosi na enwere ike ịkwenye na nkwupụta ndị a. Otu akụkọ nyocha na-ekwu na ọ bụ antioxidant dị ike ma mụọ ya maka mmetụta nchebe ya megide mmebi radieshon.

Alfa Lipoic Acid (ALA) (1077-28-7) ojiji?

Alfa-lipoic acid ma ọ bụ ALA bụ ngwakọta sitere n'okike nke emere n'ime ahụ. Ọ na-arụ ọrụ dị mkpa na ọkwa cellular, dị ka mmepụta ume. Ọ bụrụhaala na ị dị mma, ahụ nwere ike mepụta ALA niile ọ chọrọ maka ebumnuche ndị a. N'agbanyeghị eziokwu ahụ, enweela mmasị dị ukwuu n'oge na-adịbeghị anya iji ihe mgbakwunye ALA. Ndị na-akwado ALA na-ekwu na sitere na mmetụta bara uru maka ọgwụgwọ ọnọdụ dị ka ọrịa shuga na HIV iji kwalite. arọ ọnwụ.

Alfa Lipoic Acid (ALA) (1077-28-7) Ọnụọgụ ọgwụ

Mgbe a na-ewere ya dị mma, enweghị ụkpụrụ nduzi na-eduzi iji ojiji alpha-lipoic acid eme ihe n'ụzọ kwesịrị ekwesị. A na-ere ihe mgbakwunye ọnụ ọgụgụ na ntinye sitere na 100 ruo 600 mg. Dabere na ọtụtụ ihe akaebe dị ugbu a, a na-echekarị ọgwụ kachasị dị kwa ụbọchị ruo 1,800 mg ka ọ bụrụ nchekwa na ndị okenye.

N'ikwu nke a, ihe niile site na ibu ahụ na afọ ruo n'ọrụ imeju na ọrụ akụrụ nwere ike imetụta ihe dị mma maka gị n'otu n'otu. Dị ka usoro isi mkpịsị aka n'ozuzu, na-emehie n'akụkụ ịdọ aka ná ntị ma na-ahọrọ mgbe ọ bụla maka obere usoro.

Alpha ihe mgbakwunye lipoic acid enwere ike ịchọta ya n'ịntanetị na n'ọtụtụ ụlọ ahịa nri ahụike na ụlọ ahịa ọgwụ. Maka nnabata kachasị, a ga-ewere ihe mgbakwunye na afọ efu.

Alfa-lipoic Acid ntụ ntụ n'ihi na ire(Ebee ka zụta Alpha-lipoic Acid na nnukwu)

Ụlọ ọrụ anyị na-enwe mmekọrịta ogologo oge na ndị ahịa anyị n'ihi na anyị na-elekwasị anya na ndị ahịa ọrụ na inye nnukwu ngwaahịa. Ọ bụrụ na i nwere mmasị na anyị ngwaahịa, anyị na-agbanwe na customization nke iwu ona gị kpọmkwem mkpa na anyị ngwa ngwa ụzọ oge na iwu emesi ị ga-enwe oké akatabi okop ngwaahịa anyị na-oge. Anyị na-elekwasịkwa anya na ọrụ ndị bara uru. Anyị dị maka ajụjụ ọrụ na ozi iji kwado azụmahịa gị.

Anyị bụ ọkachamara Alfa-lipoic Acid ntụ ntụ soplaya ruo ọtụtụ afọ, anyị na-enye ngwaahịa na ọnụahịa asọmpi, na ngwaahịa anyị bụ nke kachasị mma ma na-enweta nnwale siri ike, nke onwe ya iji hụ na ọ dị mma maka oriri gburugburu ụwa.

References

Haenen, GRMM; Bast, A (1991). "Ngbanwe nke hypochlorous acid site na lipoic acid". Ọgwụ Ọgwụ Ọgwụ. 42 (11): 2244–6. ma ọ bụ: 10.1016 / 0006-2952 (91) 90363-A. PMID 1659823.
Biewenga, GP; Haenen, GR; Bast, A (Septemba 1997). "Nkà ọgwụ nke antioxidant lipoic acid". Ọgwụ General. 29 (3): 315–31. ma ọ bụ: 10.1016 / S0306-3623 (96) 00474-0. PMID 9378235.
Schupke, H; Hempel, R; Peter, G; Hermann, R; et al. (June 2001). "Metzọ mbu metabolic nke alpha-lipoic acid". Ọgwụ Ọgwụ na Mwepu. 29 (6): 855-62. PMID 11353754.
Acker, DS; Wayne, WJ (1957). "Optically nọ n'ọrụ na redioaktivu α-lipoic asịd". Akwụkwọ akụkọ nke American Chemical Society. 79 (24): 6483–6487. ma ọ bụ: 10.1021 / ja01581a033.
Hornberger, CS; Heitmiller, RF; Gunsalus, IC; Schnakenberg, GHF; et al. (1952). "Ihe nkwadebe nke mmiri nke lipoic acid". Akwụkwọ akụkọ nke American Chemical Society. 74 (9): 2382. doi: 10.1021 / ja01129a511.